TREATMENT FOR ALCHOLISM: A PRIMATE MODEL
TREATMENT FOR ALCHOLISM: A PRIMATE MODEL
批准号:
6362158
负责人:
Kelly P Cosgrove
金额:
$2.64万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
未结题
起止时间:
2001-03-01 至
关键词:
6,7 benzomorphan Macaca mulatta alcoholic beverage consumption alcoholism /alcohol abuse chemotherapy alcoholism antagonist biological models disease /disorder model dosage ethanol gender difference naltrexone nonhuman therapy evaluation opioid receptor oral administration reinforcer self medication stimulant /agonist
中文摘要
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英文摘要
DESCRIPTION This proposal was designed to allow for the investigation of treatments for alcoholism and the conditions under which these treatments may prove most effective. The experiments consist of examining the effectiveness of two pharmacological treatments, naltrexone, an opioid antagonist and bremazocine, a kappa opioid agonist, in reducing self- administration of oral ethanol by rhesus monkeys. Furthermore, it is possible that certain variables may influence may influence the effectiveness of treatment drugs. Therefore, the influence of an open versus closed economy on the effects of bremazocine will be investigated. An open economy allows for supplemented amounts of ethanol in addition to that which is earned, and in a closed economy the subject earns the entire amount. This paradigm allows for the investigation of the selectivity of treatment drugs. In addition, it is important to understand how ethanol-maintained behavior may differ as a function of sex. Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated.
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Enhancing dissemination and career development in sex and gender translational science in alcohol use
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批准号:10821828
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项目类别:
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资助金额:$1.25万
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财政年份:2023
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负责人:Kelly P Cosgrove
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依托单位:
Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder
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批准号:10731950
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项目类别:
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资助金额:$71.18万
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财政年份:2023
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负责人:Kelly P Cosgrove
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依托单位:
PROJECT 2: Imaging sex differences in stress-related neurochemical mechanisms of alcohol use disorders
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批准号:10357883
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项目类别:
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资助金额:$42.93万
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财政年份:2020
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负责人:Kelly P Cosgrove
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依托单位:
Translational Alcohol Research Program (TARP)
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批准号:10621155
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项目类别:
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资助金额:$33.67万
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财政年份:2020
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负责人:Kelly P Cosgrove
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依托单位:
PROJECT 2: Imaging sex differences in stress-related neurochemical mechanisms of alcohol use disorders
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批准号:10599823
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项目类别:
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资助金额:$33.87万
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财政年份:2020
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负责人:Kelly P Cosgrove
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依托单位:
Translational Alcohol Research Program (TARP)
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批准号:10396641
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项目类别:
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资助金额:$28.43万
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财政年份:2020
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负责人:Kelly P Cosgrove
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依托单位:
Translational Alcohol Research Program (TARP)
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批准号:10159175
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项目类别:
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资助金额:$45.17万
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财政年份:2020
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Microglial Activation in PTSD with PET
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批准号:10004712
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项目类别:
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资助金额:$75.33万
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财政年份:2017
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Microglial Activation in PTSD with PET
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批准号:9309643
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项目类别:
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资助金额:$83.75万
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财政年份:2017
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Molecular Mechanisms of Tobacco Smoking Withdrawal
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批准号:9232117
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项目类别:
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资助金额:$73.83万
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财政年份:2016
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Molecular Mechanisms of Tobacco Smoking Withdrawal
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批准号:9841911
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项目类别:
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资助金额:$69.25万
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财政年份:2016
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负责人:Kelly P Cosgrove
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依托单位:
Microglial activation in alcohol dependence: A [C-11]PBR28 PET study.
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批准号:8701198
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项目类别:
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资助金额:$23.22万
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财政年份:2013
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负责人:Kelly P Cosgrove
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依托单位:
Microglial activation in alcohol dependence: A [C-11]PBR28 PET study.
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批准号:8582744
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项目类别:
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资助金额:$19.77万
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财政年份:2013
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Genetics in Tobacco Smokers
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批准号:8655837
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项目类别:
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资助金额:$12.68万
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财政年份:2012
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Genetics in Tobacco Smokers
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批准号:8456096
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项目类别:
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资助金额:$12.68万
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财政年份:2012
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Genetics in Tobacco Smokers
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批准号:8299887
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项目类别:
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资助金额:$12.68万
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财政年份:2012
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负责人:Kelly P Cosgrove
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依托单位:
Imaging Nicotinic Acetylcholine Receptors in Schizophrenia
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批准号:7772353
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项目类别:
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资助金额:$28.89万
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财政年份:2009
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负责人:Kelly P Cosgrove
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依托单位:
GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
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批准号:8243690
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项目类别:
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资助金额:$53.74万
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财政年份:2009
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负责人:Kelly P Cosgrove
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依托单位:
Dopaminergic and Endocannabinoid Interactions in Nicotine Dependence
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批准号:7573403
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项目类别:
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资助金额:$19.47万
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财政年份:2009
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负责人:Kelly P Cosgrove
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依托单位:
GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
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批准号:7783876
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项目类别:
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资助金额:$44.89万
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财政年份:2009
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负责人:Kelly P Cosgrove
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依托单位:
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太行山猕猴(Macaca mulatta tcheliensis)雌性的配偶选择
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