VISUAL-MOTOR TRANSFORMATIONS IN PARIETAL CORTEX

顶叶皮层的视觉运动转换

• 批准号: 6350875
• 负责人: Lawrence H Snyder
• 金额: $ 23.89万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6350875
• 关键词: Primates; arm; behavior test; body movement; brain mapping; eye movements; head movements; limb movement; neural information processing; parietal lobe /cortex; sensorimotor system; space perception; visual stimulus

DESCRIPTION (Adapted From The Applicant's Abstract): This proposal will investigate the role of the posterior parietal cortex in directing movements to visible targets. The parietal cortex clearly plays a role in this process, but the nature of that role is unresolved. Complicating the issue is the fact that parietal cortex contains multiple fields, many of which are involved in the processing of visual spatial information, and some of which appear to be related to the movements of particular body parts. A common approach to studying the role of these fields in transforming sensory information into motor commands has been to consider the frame of reference of the spatial information that each contains. The PI now proposes to study, in addition, whether and how the information is specifically related to arm, eye and head movements (motor specificity). The development of motor specific responses relates to the selection of a particular motor response, a critical stage in the sensory to motor transformation. It is suggested that response selection and reference frame transformation are two distinct and potentially separable components of that transformation. This approach is a significant departure from previous work, which has typically considered only a single motor output. Aim I will characterize the exact relationship between motor specificity and frame of reference for activity in the ventral intraparietal area (VIP). The experiments and their analysis are designed to capture the full range and potential richness of the properties of individual neurons, rather than merely categorizing them as "motor" or "sensory." Aim 2 will examine motor-specific activity in the lateral intraparietal area (LIP) and in the parietal reach region (PRR). We will determine how signals encoding the decision to take one course of action or another interact with signals encoding spatial information. Finally, Aim 3 will challenge an established hypothesis concerning spatial information processing in LIP. The hypothesis has important ramifications for whether processing may be directed towards specific motor outputs. Taken together, the results of these aims are likely to provide new insight into the role of parietal cortex in the sensory to motor transformation in general, and in particular, into the role of specific fields in directing eye, arm and head movements to visual targets.

描述（改编自申请人摘要）：本提案将 研究后顶叶皮层在指导运动中的作用， 可见目标顶叶皮层显然在这个过程中发挥了作用，但 这一作用的性质尚未得到解决。使问题复杂化的是， 顶叶皮层包含多个区域，其中许多区域参与了 视觉空间信息的处理，其中一些似乎是 与特定身体部位的运动有关。的共同办法 研究这些领域在将感官信息转化为 运动指令一直在考虑空间的参考系， 每个人都包含的信息。此外，PI现在建议研究， 信息是否和如何与手臂、眼睛和头部具体相关 运动特异性（motor specificity）运动特异性反应的发展 与特定运动反应的选择有关，这是 从感觉到运动的转变建议响应选择 和参考坐标系变换是两个不同的和潜在可分离的 这种转变的组成部分。这种方法是一种重大的背离 从以前的工作，通常只考虑一个单一的电机输出。 目的我将描述运动特异性和 腹侧顶内区（VIP）活动的参照系。的 实验及其分析的目的是捕捉整个范围， 单个神经元特性的潜在丰富性，而不仅仅是 将其归类为“运动”或“感觉”。“Aim 2将检查特定于 活动在外侧顶内区（LIP）和顶叶达到 区域（PRR）。我们将确定信号编码如何决定采取一个 动作过程或另一个与编码空间信息的信号相互作用。 最后，目标3将挑战一个关于空间的既定假设， LIP中的信息处理这一假设对以下问题有重要的影响： 处理是否可以针对特定的电动机输出。采取 总之，这些目标的结果很可能为我们提供新的见解， 顶叶皮层在感觉到运动转换中的作用，以及 特别是，进入特定领域的作用，在指导眼睛，手臂和头部， 移动到可视目标。