Dysferlin coordinates membrane repair for skeletal and cardiac injury

Dysferlin 协调骨骼和心脏损伤的膜修复

• 批准号: nhmrc : 1048816
• 负责人: A/Pr Sandra Cooper
• 金额: $ 30.62万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dysferlin-coordinates-membrane-cardiac-injury/112040
• 关键词: Dysferlin; coordinates; membrane; repair; skeletal

Muscles are damaged all of the time, as we stretch and contract them, but we don't fully understand how they repair themselves. We are studying the molecular steps taken by a muscle cell to repair membrane damage. Our research will provide valuable insights into how to treat muscular dystrophy and other conditions characterised by membrane damage to cells, such as heart attack and stroke.

当我们拉伸和收缩肌肉时，肌肉一直在受损，但我们并不完全了解它们是如何自我修复的。我们正在研究肌肉细胞修复膜损伤的分子步骤。我们的研究将为如何治疗肌营养不良症和其他以细胞膜损伤为特征的疾病提供有价值的见解，如心脏病发作和中风。