MECHANISM(S) CONTROLLING GROWTH/MEIOSIS SWITCH IN YEAST

酵母中控制生长/减数分裂转换的机制

基本信息

  • 批准号:
    6386969
  • 负责人:
  • 金额:
    $ 16.24万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-08-01 至 2003-08-31
  • 项目状态:
    已结题

项目摘要

The switch between differentiation and growth is precisely regulated in all organisms. Loss of this control in humans can lead to cancer. Differentiation/growth switches are generally controlled by multiple extracellular signals, but analyzing the relationship between different controls is difficult in most systems. A simple prototype exists in diploid yeast, where three different types of control (cell cycle, glucose and acetate interact to regulate the switch between growth and meiosis. Yeast genetics provides a powerful tool for analyzing these different layers of control both separately and in combination. A central feature of growth/differentiation switches is that the two programs are mutually exclusive: cells must shut down one program to undergo the other. A recent finding the lab sheds light on this mechanism: the same proteins that trigger growth (cyclins) also repress initiation of meiosis. By measuring expression of specific meiotic regulators under conditions where cyclins are either absent or overexpressed, the mechanisms underlying repression of meiosis by cyclins will be defined (Specific Aim 1). The investigator has discovered the IME1 transcription is regulated like a 3-position switch; it is completely repressed under growth conditions, expressed to high levels under sporulation conditions, and expressed to moderate levels under conditions of carbon deprivation. The moderate level IME1 expression causes some cells to undergo recombination without chromosome segregation. This novel mechanism for transcriptional regulation, which involves interactions between several levels of control, will be dissected using a combination of yeast genetics and molecular biology (Specific Aim 2). Extracellular signals are generally considered to act at the beginning of a differentiation program, triggering a continuous progression of cellular changes. The investigator made the intriguing discovery that meiosis in yeast responds to extracellular signals at two distinct stages: prior to premeiotic DNA synthesis (early) and prior to chromosome segregation (late), and that the regulation at the two stages is different. To further examine this two-step control of differentiation, genes involved in nutritional control of late meiotic events are being identified, and their interactions with known meiotic regulators characterized (Specific Aim 3).
分化和生长之间的转换在

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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SAUL M HONIGBERG其他文献

SAUL M HONIGBERG的其他文献

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{{ truncateString('SAUL M HONIGBERG', 18)}}的其他基金

Admin. supplement for equipment to Mechanisms underlying the Rlm1-dependent G1 checkpoint (NIH R15 GM135807)
行政。
  • 批准号:
    10598250
  • 财政年份:
    2020
  • 资助金额:
    $ 16.24万
  • 项目类别:
Mechanisms underlying cell-fate patterns in yeast communities
酵母群落细胞命运模式的潜在机制
  • 批准号:
    8626605
  • 财政年份:
    2010
  • 资助金额:
    $ 16.24万
  • 项目类别:
Mechanisms underlying cell-fate patterns in yeast communities
酵母群落细胞命运模式的潜在机制
  • 批准号:
    9305292
  • 财政年份:
    2010
  • 资助金额:
    $ 16.24万
  • 项目类别:
Mechanisms underlying pattern formation in S. cerevisiae colonies
酿酒酵母菌落模式形成的机制
  • 批准号:
    8242306
  • 财政年份:
    2010
  • 资助金额:
    $ 16.24万
  • 项目类别:
Mechanisms underlying pattern formation in S. cerevisiae colonies
酿酒酵母菌落模式形成的机制
  • 批准号:
    7981244
  • 财政年份:
    2010
  • 资助金额:
    $ 16.24万
  • 项目类别:
Mechanisms underlying pattern formation in S. cerevisiae colonies
酿酒酵母菌落模式形成的机制
  • 批准号:
    8462760
  • 财政年份:
    2010
  • 资助金额:
    $ 16.24万
  • 项目类别:
Gene Regulatory Codes and Signal/Regulatory Element Interactions in IME2
IME2 中的基因调控代码和信号/调控元件相互作用
  • 批准号:
    7896207
  • 财政年份:
    2009
  • 资助金额:
    $ 16.24万
  • 项目类别:
Gene Regulatory Codes and Signal/Regulatory Element Interactions in IME2
IME2 中的基因调控代码和信号/调控元件相互作用
  • 批准号:
    7254454
  • 财政年份:
    2007
  • 资助金额:
    $ 16.24万
  • 项目类别:
MECHANISM(S) CONTROLLING GROWTH/MEIOSIS SWITCH IN YEAST
酵母中控制生长/减数分裂转换的机制
  • 批准号:
    6417162
  • 财政年份:
    1998
  • 资助金额:
    $ 16.24万
  • 项目类别:
MECHANISM(S) CONTROLLING GROWTH/MEIOSIS SWITCH IN YEAST
酵母中控制生长/减数分裂转换的机制
  • 批准号:
    6180905
  • 财政年份:
    1998
  • 资助金额:
    $ 16.24万
  • 项目类别:

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ROLE OF CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
细胞粘附在生物信号转导中的作用
  • 批准号:
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  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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  • 批准号:
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  • 项目类别:
CELL ADHESION IN BIOLOGICAL SIGNAL TRANSDUCTION
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  • 批准号:
    3732412
  • 财政年份:
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  • 项目类别:
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