RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES

上呼吸道肌肉的呼吸相关运动输出

• 批准号: 6388882
• 负责人: SAMUEL T. KUNA
• 金额: $ 35.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-07-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6388882
• 关键词: afferent nerve; biomechanics; cats; decerebration; fiber optics; hypercapnia; larynx muscle; lung; motor neurons; muscle contraction; neuromuscular transmission; pharynxs; pulmonary respiration; respiratory airway volume; sensorimotor system; sensory feedback; tongue; trachea; vagus nerve

DESCRIPTION (Adapted from the Applicant's Abstract): The purpose of this proposal is to perform experiments in decerebrate cats to examine four specific aims: 1. To determine the neural input from the Kolliker-Fuse nucleus (KFN) to pharyngeal respiratory muscle motoneurons located in the hypoglossal nucleus (HGN). In addition, to neural pathways, neuromediator activity of the KLN will be explored. 2. To determine the effect of airway length on the mechanical effects of pharyngeal constrictor muscle contraction. It is hypoothesized that upper airway shortening may alter the mechanical effect of contraction of these muscles, such that they will have dilatory instead of constricting action. 3. To determine the effect of vagal afferent activity on pharyngeal muscle constrictor action. It is proposed that the pharyngeal muscles that are usually pharyngeal constrictors may become dilator muscles during hypercapnia in the absence of afferent vagal feedback. 4. To determine the changes in regional structure during contracture of various pharyngeal muscles by the use of retrograde fiberoptic imaging in a closed upper airway. This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania.

描述（改编自申请人的摘要）：本申请的目的是 一项提议是在去大脑猫中进行实验，以检查四种特定的 目标：1.为了确定从Kolliker-Ehrmann核（KFN）到 位于舌下神经核的咽呼吸肌运动神经元 （HGN）。此外，对于神经通路，KLN的神经介质活性将 被探索。2.为了确定气道长度对机械 咽缩肌收缩的影响。这是一种假设， 上呼吸道缩短可改变这些呼吸道收缩的机械效应， 肌肉，使他们将有扩张而不是收缩行动。3. 确定迷走神经传入活动对咽肌的影响 收缩作用。据建议，咽肌通常是 咽缩肌在高碳酸血症期间可变为扩张肌， 没有传入迷走神经反馈。4.为了确定区域变化， 结构在挛缩的各种咽肌的使用 在闭合的上气道中进行逆行光纤成像。这项工作是一个 扩大PI迄今为止开展的工作，PI最近已搬迁到 宾夕法尼亚大学