SLEEP & FRONTAL LOBE FUNCTION IN REHAB FROM STROKE & TRAUMATIC BRAIN INJURY

睡觉

• 批准号: 6566701
• 负责人: SAMUEL T. KUNA
• 金额: $ 27.93万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6566701
• 关键词: brain injury; clinical research; frontal lobe /cortex; human subject; neuroanatomy; neuropsychological tests; rehabilitation; single photon emission computed tomography; sleep; stroke

Sleep disturbance can be significant after brain damage due to trauma or stroke, but little is known regarding its prevalence and consequences. Patients often complain of symptoms of disturbed sleep and lack of dreaming, and demonstrate inattentiveness, memory difficulties, and easy fatigability, which are commonly associated with sleep disturbance in uninjured populations. In this protocol the sleep of a representative sample of TBI and stroke patients will precisely characterized, and the findings correlated with independent observations of brain function as delineated through formal neuropsychological evaluation. Subjects will be evaluated while attending the post-acute rehabilitation program of the Transitional Learning Community in Galveston. The results will increase our understanding of brain behavior relationships, and provide a scientific basis for intervening beneficially in these populations with better behavioral and pharmacological therapies Such interventions may directly improve quality of life in these patients and enable them to better engage in other rehabilitation efforts. Because stroke and trauma are leading causes of brain damage in the U.S., and cause considerable disability as well as expenditure for health care and rehabilitation, these results could have major public health impact.

由于创伤或中风导致的脑损伤后，睡眠障碍可能很严重，但对其患病率和后果知之甚少。患者经常抱怨睡眠障碍和缺乏梦想的症状，并表现出注意力不集中，记忆困难和容易疲劳，这通常与未受伤人群的睡眠障碍有关。 在该方案中，将精确表征TBI和中风患者的代表性样本的睡眠，并且发现与通过正式神经心理学评估描绘的脑功能的独立观察相关。 受试者将在参加加尔维斯顿过渡学习社区的急性期后康复计划时接受评估。 这些结果将增加我们对大脑行为关系的理解，并为通过更好的行为和药物治疗对这些人群进行有益的干预提供科学依据。这些干预可能直接改善这些患者的生活质量，并使他们能够更好地参与其他康复工作。 因为中风和创伤是美国脑损伤的主要原因，并造成相当大的残疾以及医疗保健和康复支出，这些结果可能会对公共卫生产生重大影响。