Quantative image analysis of positron emmisions tomography for inflammation research

用于炎症研究的正电子发射断层扫描的定量图像分析

• 批准号: 1685763
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1685763
• 关键词: Quantative; image; analysis; positron; emmisions

Lung diseases are one of the leading causes of death in the UK; responsible for 20% of all deaths each year. Diffuse Parenchymal Lung Diseases (DPLDs) describe a spectrum of different diseases; characterised by widespread inflammation and fibrosis, they represent a significant burden to the healthcare sector. Development of effective therapeutic treatments has been stifled by a lack of sensitive biomarkers. There is considerable interest in the role of imaging biomarkers in the field of pulmonary diseases, this is in part due to the shortcomings of existing methods to evaluate lung function. Molecular imaging, in particular, may be able to elucidate the fundamental molecular basis of lung diseases and promote the translation into effective therapies. 18F-FDG PET has been established within the research community as a technique that may allow the in-vivo measurement of lung inflammation. However, there has been criticisms of 18F-FDG PET in the context of pulmonary inflammation which are compounded by the technical challenges of imaging the lungs. There is currently no accepted method of quantification of 18F-FDG PET scans to assess lung inflammation; indeed, the difficulty of providing appropriate validation for the imaging techniques has contributed to the lack of standardisation. Taken together this limits its potential use as a biomarker. The objective of this project is to develop an image analysis pipeline to assess lung inflammation, compare competing analysis techniques and validate the models used. This will be achieved through two studies: a prospective study of sarcoidosis patients and healthy volunteers; and a retrospective study of Chronic Obstructive Pulmonary Disease (COPD) patients.

在英国，肺部疾病是主要的死亡原因之一；每年占所有死亡人数的20%。弥漫性实质性肺病(DPLD)描述了一系列不同的疾病；以广泛的炎症和纤维化为特征，它们给医疗保健部门带来了沉重的负担。由于缺乏敏感的生物标记物，有效的治疗方法的开发受到了阻碍。成像生物标记物在肺部疾病领域的作用引起了相当大的兴趣，这在一定程度上是由于现有评估肺功能的方法的缺陷。特别是，分子成像可能能够阐明肺部疾病的基本分子基础，并促进将其转化为有效的治疗方法。18F-FDG正电子发射计算机断层扫描(18F-FDG PET)已经在研究界被确立，作为一种可能允许在体内测量肺部炎症的技术。然而，在肺部炎症的背景下，18F-FDG PET一直受到批评，而肺部成像的技术挑战加剧了这一问题。目前还没有公认的18F-FDG PET扫描的量化方法来评估肺部炎症；事实上，为成像技术提供适当的验证的困难导致了缺乏标准化。综上所述，这限制了它作为生物标志物的潜在用途。该项目的目标是开发一种图像分析管道，以评估肺部炎症，比较竞争分析技术，并验证所使用的模型。这将通过两项研究来实现：结节病患者和健康志愿者的前瞻性研究；以及慢性阻塞性肺疾病(COPD)患者的回顾研究。