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Pathways from socioeconomic deprivation to bronchiolitis and subsequent childhood asthma

从社会经济剥夺到细支气管炎和随后的儿童哮喘的途径

基本信息

批准号：
1764985
负责人：
金额：
--
依托单位：
University College London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1764985
关键词：
Pathways socioeconomic deprivation bronchiolitis subsequent

项目摘要

Acute and chronic respiratory conditions are a major cause of morbidity amongst children in the UK, and are responsible for substantial burden on children, their families and the health care system. In infants, infection of the lungs (bronchiolitis) is the most common cause of hospitalisation in England. Asthma is another respiratory condition that is highly prevalent amongst children in the UK. Despite wide agreement that hospital admission for acute respiratory infection is associated with an increased risk of asthma at an older age, there is an ongoing debate about the nature of this association. Discussions focus on a directly causative or a genetic predetermined signal explanation to explain this relationship, without fully considering the role of other risk factors. An overriding facet of both conditions is the inequity in prevalence across socioeconomic groups. An unknown proportion of the association between socio-economic status, infant bronchiolitis, and subsequent asthma is due, to common risk factors operating in utero such as tobacco smoke exposure, fetal growth and prematurity. It is therefore important, as there is no cure available for the majority of these conditions, that we fully understand what causes these health problems to occur. This is particularly important amongst children who are known to be socially disadvantaged, and are placed at a greater risk for these diseases and other chronic conditions.The overall aim of this project is to understand the causal pathways between socioeconomic deprivation and respiratory conditions in early and mid-childhood (see Figure 1). I will primarily use national English and Scottish birth cohorts, created from administrative health records, to meet the specific study objectives: 1. To describe the association between socioeconomic deprivation, seasonality and acute respiratory infection in infancy 2. To establish to what extent maternal and perinatal risk factors, including in-utero pollution exposure, mode of delivery, birth weight, gestational age and chronic conditions mediates the association between socioeconomic deprivation and acute respiratory infection in infancy 3. To describe asthma/wheeze phenotypes in children aged <10 years old and their associated risk factors, including socio-economic position 4. To determine the total contribution of early acute respiratory infection to the effect of socio-economic deprivation on mid-childhood asthma/wheeze phenotypes. Overall, I will determine at what time, and for which risk factors, interventions would reduce the most inequity and overall burden of respiratory conditions in childhood.

急性和慢性呼吸道疾病是英国儿童发病率的主要原因，给儿童、他们的家庭和卫生保健系统造成了沉重的负担。在婴儿中，肺部感染(毛细支气管炎)是英格兰最常见的住院原因。哮喘是另一种在英国儿童中非常普遍的呼吸系统疾病。尽管人们普遍认为，急性呼吸道感染入院与老年哮喘风险增加有关，但关于这种联系的性质仍在进行辩论。讨论的重点是直接原因或遗传预定的信号解释来解释这种关系，而没有充分考虑其他危险因素的作用。这两种情况的一个重要方面是在社会经济群体中普遍存在的不平等。在社会经济地位、婴儿毛细支气管炎和随后的哮喘之间的关联中，未知比例是由于共同的风险因素，如吸烟暴露、胎儿发育和早产。因此，重要的是，由于这些疾病中的大多数都无法治愈，我们必须充分了解导致这些健康问题发生的原因。这在已知处于社会不利地位的儿童中尤其重要，他们罹患这些疾病和其他慢性疾病的风险更大。本项目的总体目标是了解儿童早期和中期社会经济贫困和呼吸疾病之间的因果关系(见图1)。我将主要使用国家英格兰和苏格兰的出生队列，这些队列是根据行政健康记录创建的，以满足特定的研究目标：1.描述社会经济贫困、季节性和婴儿期急性呼吸道感染之间的联系2.建立母亲和围产期危险因素，包括宫内污染暴露、分娩方式、出生体重、胎龄和慢性疾病在多大程度上调节社会经济贫困和婴儿期急性呼吸道感染之间的关系3.描述年龄和年龄的儿童哮喘/喘息的表型；10岁及其相关危险因素，包括社会经济状况4.确定早期急性呼吸道感染对社会经济剥夺对儿童中期哮喘/喘息表型影响的总贡献。总体而言，我将决定在什么时候以及针对哪些风险因素进行干预，以减少儿童时期呼吸道状况最不公平和总体负担最大的情况。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Is socioeconomic position associated with bronchiolitis seasonality? A cohort study

DOI：
10.1136/jech-2019-213056
发表时间：
2021-01-01
期刊：
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
影响因子：
6.3
作者：
Lewis, Kate;De Stavola, Bianca;Hardelid, Pia
通讯作者：
Hardelid, Pia

Socioeconomic position, bronchiolitis and asthma in children: counterfactual disparity measures from a national birth cohort study.

DOI：
10.1093/ije/dyac193
发表时间：
2023-04-19
期刊：
International journal of epidemiology
影响因子：
7.7
作者：
通讯作者：

Mother's education and offspring asthma risk in 10 European cohort studies.

DOI：
10.1007/s10654-017-0309-0
发表时间：
2017-09
期刊：
European journal of epidemiology
影响因子：
13.6
作者：
Lewis KM;Ruiz M;Goldblatt P;Morrison J;Porta D;Forastiere F;Hryhorczuk D;Zvinchuk O;Saurel-Cubizolles MJ;Lioret S;Annesi-Maesano I;Vrijheid M;Torrent M;Iniguez C;Larranaga I;Harskamp-van Ginkel MW;Vrijkotte TGM;Klanova J;Svancara J;Barross H;Correia S;Jarvelin MR;Taanila A;Ludvigsson J;Faresjo T;Marmot M;Pikhart H
通讯作者：
Pikhart H

National data opt out programme: consequences for maternity statistics in England.

国家数据选择退出计划：对英格兰生育统计的影响。