Environmental Exposures & Sleep in the Nurses' Health Study 3

环境暴露

• 批准号: 10677271
• 负责人: Cindy Robin Hu
• 金额: $ 4.54万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677271
• 关键词: 18 year old; Accelerometer; Address; Adult; Affect; Agreement; Air Pollution; Anxiety; Arts; Behavior; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Chronic; Cognition; Complex; Development; Diabetes Mellitus; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Exposure to; Fellowship; Female; Future; Geographic Distribution; Geography; Goals; Gold Alloys; Green space; Health; Health Status; Health Technology; Health behavior; Hour; Human; Humidity; Individual; Investigation; Joints; Light; Link; Location; Longitudinal cohort; Maintenance; Measurement; Measures; Mediating; Mediation; Mental Depression; Mental Health; Mentorship; Metabolic; Neighborhoods; Nurses; Nurses' Health Study; Nursing Students; Obesity; Outcome; Pathway interactions; Patient Self-Report; Performance; Physical activity; Physiological; Polysomnography; Population; Positioning Attribute; Process; Prospective cohort; Public Health Schools; Recommendation; Recording of previous events; Recovery; Reporting; Research; Resources; Risk; Risk Factors; Role; Science; Seasons; Shapes; Sleep; Sleep Deprivation; Socioeconomic Status; Source; Temperature; Time; Training; United States; Universities; Validation; Woman; Wrist; actigraphy; built environment; cohort; doctoral student; epidemiology study; experience; fitbit; graduate school; health data; health determinants; insight; interest; mHealth; male; men; physical conditioning; population health; pre-doctoral; public health intervention; repaired; sleep health; smartphone application; social; tool; walkability; wearable device

PROJECT SUMMARY The goal of this F31 fellowship application is to support and promote the training of Cindy R. Hu, currently a pre-doctoral student in the Department of Environmental Health of the Harvard TH Chan School of Public Health and the Graduate School of Arts and Sciences at Harvard University. Her long-term research interests focus on the associations of multiple environmental exposures on sleep. Ms. Hu has assembled a group of leading experts as her Sponsors and Co-Sponsors including Drs. Jaime Hart, Brent Coull, Peter James, and Susan Redline. Sleep is an important component of human health; it is a process that serves key functions in cognition, performance, physiological repair, and recovery. Inadequate sleep has been linked to many physical health outcomes like cardiovascular disease, diabetes, and obesity, as well as mental health outcomes such as anxiety and depression. A nation-wide analysis showed an uneven geographic distribution of insufficient sleep across the US; this geographic variability may be explained by a confluence of social and environmental determinants of health. Environmental exposures that shape one’s sleeping environment as well as exposures that are experienced during wake can impact sleep health. Of particular interest due to their modifiability are built environment factors, such as light at night, neighborhood greenspace, and walkability have been shown to affect sleep. Currently, environmental epidemiological studies of sleep often rely on self-reported measures of sleep. The development of mobile health technologies provides an opportunity to quantitatively measure sleep in ecologically valid and free-living (i.e. non-laboratory) conditions on a larger scale, but requires validation against research standards. In addition to quantitative assessments of sleep, mobile health data can provide rich information on GPS location and behaviors like physical activity, which allow for investigation of mechanisms that link environmental exposures to sleep. Another key aspect of furthering our understanding of how the environment impacts sleep is the utilization of an exposomic framework; to our knowledge, no study has examined the effects of multiple exposures on sleep. Using the unique resources of the Nurses’ Health Study 3 (NHS3) longitudinal cohort, Ms. Hu will receive extensive training in multiple aspects of exploring the impacts of the environment on sleep, ranging from how to compare objective measures from multiple sources (Aim 1), using mobile health panel studies to examine associations between features of the built environment on sleep outcomes (Aim 2), and how to scale these insights to a full cohort of US women and men (Aim 3). This will position her to be a future leader in the field of the environment and sleep through high-quality mentorship and extensive professional development opportunities.

项目摘要 这个F31奖学金申请的目的是支持和促进辛迪R的培训。目前，A 哈佛TH Chan公共卫生学院环境卫生系博士预科生 以及哈佛大学艺术与科学研究生院。她的长期研究兴趣集中在 多种环境暴露对睡眠的影响。胡女士召集了一批 专家作为她的赞助商和共同赞助商，包括Jaime哈特博士、布伦特考尔博士、彼得詹姆斯博士和苏珊博士 红线睡眠是人类健康的重要组成部分;它是一个在认知中发挥关键作用的过程， 性能、生理修复和恢复。睡眠不足与许多身体健康有关 心血管疾病、糖尿病和肥胖等后果，以及焦虑等心理健康后果， 和抑郁症一项全国范围的分析显示，睡眠不足的地理分布不均匀， 美国;这种地理变异性可以用社会和环境决定因素的汇合来解释 of health.影响睡眠环境的环境暴露以及影响睡眠环境的环境暴露 在清醒时的经历会影响睡眠健康。由于其可修改性， 环境因素，如夜间光线，邻里绿地和步行能力已被证明， 影响睡眠目前，睡眠的环境流行病学研究往往依赖于自我报告的测量， 睡吧移动的健康技术的发展提供了定量测量睡眠的机会 在生态有效和自由生活（即非实验室）的条件下，在更大的规模，但需要验证 违反研究标准。除了对睡眠进行定量评估外，移动的健康数据还可以提供 丰富的GPS位置和行为信息，如身体活动，这使得调查 将环境暴露与睡眠联系起来的机制进一步了解的另一个关键方面 环境如何影响睡眠是一个经济学框架的利用;据我们所知，没有研究 研究了多次暴露对睡眠的影响。利用护士健康的独特资源 研究3（NHS 3）纵向队列，胡女士将接受多方面的广泛培训，探索 环境对睡眠的影响，从如何比较来自多个来源的客观指标， (Aim 1），使用移动的健康小组研究，以检查建筑环境特征之间的关联 关于睡眠结果（目标2），以及如何将这些见解扩展到美国女性和男性的完整队列（目标3）。这 将她定位为环境领域的未来领导者，并通过高质量的指导睡眠 广泛的专业发展机会。