MRFASS--MINORITIES, RISK FACTOR AND STROKE STUDY

MRFASS--少数民族、危险因素和中风研究

• 批准号: 6393484
• 负责人: STANLEY TUHRIM
• 金额: $ 86.2万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393484
• 关键词: African American; Hispanic Americans; cardiovascular disorder epidemiology; caucasian American; clinical research; disease /disorder proneness /risk; human subject; longitudinal human study; pathologic process; racial /ethnic difference; relapse /recurrence; stroke

DESCRIPTION: (Adapted from Applicant's Abstract). The purposes of this project are both to determine the risk of recurrent stroke in three urban ethnic groups, African-Americans, Latinos, and white non-Latinos and to determine the risk factors for recurrence in these groups. African-Americans and Latinos appear to be at greater risk, not only for initial stroke, but also for stroke recurrence. As the population ages and stroke mortality declines, the number of people at risk for recurrent stroke rises. At least 25% of hospital admissions for stroke are recurrent strokes. Recurrent stroke is therefore a large and growing public health concern. Since patients with stroke come to medical attention they are an easily identified group of people in need of preventive health measures. Identifying the major components of their recurrent stroke risk will provide a focus for these measures. To identify recurrent risk factors in the groups under study, a cohort of approximately 990 patients will be enrolled over a six year period and followed for up to four years. Putative risk factors for recurrent stroke will be identified at the time of index stroke. Control of major risk factors including hypertension, hyperglycemia, smoking, alcohol use and compliance with prescribed treatment will be monitored annually by in-person follow-up. Measures of end-organ involvement (viz., carotid artery wall thickness, left ventricular hypertrophy and compliance) will be obtained at two years post-stroke. Stroke-free survival rates will be estimated for each ethnic group and the independent determinants of recurrence will be identified with multivariate statistical techniques.

描述：（改编自申请人摘要）。 施行本 两个项目都是为了确定三个城市中风复发的风险， 种族群体，非洲裔美国人，拉丁美洲人和白色非拉丁美洲人， 确定这些人群中复发的风险因素。 非洲裔美国人和拉丁美洲人似乎面临更大的风险，不仅因为 首次中风，但也为中风复发。 随着人口老龄化和 中风死亡率下降，有中风复发风险的人数 上升。 至少25%的中风住院患者是复发性的 中风 因此，复发性卒中是一个庞大且不断增长的公共卫生问题， 关心 由于中风患者前来就医， 需要采取预防性保健措施的容易识别的人群。 确定其复发性卒中风险的主要组成部分将提供 这些措施的重点。 为了确定研究组中复发的风险因素， 在六年的时间内将招募大约990名患者， 随访了四年。 复发性卒中的假定危险因素 将在索引中风时被识别。 重大风险控制 包括高血压、高血糖、吸烟、饮酒和 每年将亲自监测处方治疗的依从性 随访 终末器官受累的测量（即，颈动脉壁 厚度、左心室肥大和顺应性）将在 中风后两年 无卒中生存率将估计为 每个种族群体和复发的独立决定因素将是 用多变量统计技术鉴定。