MRFASS MINORITIES RISK FACTORS AND STROKE STUDY

MRFASS 少数族裔危险因素和中风研究

• 批准号: 3416638
• 负责人: STANLEY TUHRIM
• 金额: $ 47.75万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3416638
• 关键词: African American; Hispanic Americans; blood chemistry; blood lipid; caucasian American; community health services; diabetes mellitus; disease /disorder proneness /risk; echocardiography; electrocardiography; glucose metabolism; heart disorder; hemoglobin As; human middle age (35-64); human old age (65+); human population study; human subject; hypertension; interview; mathematical model; medical records; pathologic process; statistics /biometry; stroke; ultrasonography

The goal of this project is to better understand the etiology of stroke in all segments of our society and identify what differences exist between these segments so that programs for stroke prevention may be designed for minority populations addressing potent, modifiable risk factors for stroke in these communities. The primary hypothesis to be tested is: The increased risk of stroke in the African-American and Hispanic populations is due to an increased prevalence of recognized factors for stroke as determined primarily from studies of whites. Based on observations of stroke admissions during the past two years, it is anticipated that 750 incident stroke cases can be recruited from admissions to these facilities in 3.25 years. Of these, 150 will be Hispanic, 225 will be African-American and 375 will be white. Each Hispanic and African- American case will be matched with two neighborhood controls of the same ethnicity, while whites will be matched on a one-to-one basis. Controls will be recruited with the aid of community organizations with whom Mount Sinai has an ongoing relationship. Information regarding stroke risk factors, including hypertension, diabetes, smoking, serum lipids, carotid and cardiac disease, will be obtained by interview, blood sampling, EKG and ultrasound evaluations. From these data, multiple logistic regression models will be developed to estimate the relative and attributable risk associated with these factors for each of these groups. It will then be possible to determine if there are clinically important differences in risk factor configurations among these groups.

该项目的目标是更好地了解中风的病因， 我们社会的所有部门，并确定存在什么差异之间 这些部分，使中风预防计划可以设计， 少数人群解决卒中的潜在、可改变的风险因素 in these communities社区. 要检验的主要假设是： 非裔美国人和西班牙裔人群中卒中风险增加 是由于中风的公认因素的患病率增加， 主要是通过对白人的研究得出的。 根据对过去两年中风入院的观察， 预计可从入院患者中招募750例突发性卒中病例 在3.25年内完成 其中，150人将是西班牙裔，225人 将是非裔美国人，375人是白色。 每一个西班牙裔和非洲裔- 美国病例将与两个相同的社区对照组相匹配 种族，而白人将在一对一的基础上匹配。 控制 将在社区组织的帮助下招募， 西奈半岛有一个持续的关系。 关于中风风险的信息 影响因素包括高血压、糖尿病、吸烟、血脂、颈动脉 和心脏病，将通过面谈、血样采集、EKG和 超声评估。 根据这些数据，多元Logistic回归 将开发模型来估计相对和可归因风险 与这些因素相关的因素。 然后它将 可以确定风险是否存在临床重要差异 这些群体之间的因素配置。