MULTICHANNEL SENSORS FOR NEUROSCIENCES

该技术开发计划的目标是为神经科学创建多通道电压和化学传感器系统的制造和开发资源。 其目的是为了满足利用美国高密度电子学中心最近开发的新的微电路制造技术的需要。在S博士的指导下，阿肯色州。埃 该计划将同时致力于四个主要目标。 第一个目标是制造新一代的小型硅基多位点微探针，其位点专门用于电压或电化学传感。传感器位置特性的评估和研究将由I Fritsch博士（美国）进行。方舟.），D.伍德沃德（维克森林大学），和R. M。怀特曼（联合国卡罗莱纳）。 第二个目标是将硅探头集成到柔性聚酰亚胺电缆系统中。 用于制造和涂覆这种材料的新技术将适用于体内神经科学应用。 第三个目标是设计和制造多通道超大规模集成电路微芯片头台设备，以放大和传输来自电压和电化学传感器位置的信息。 芯片设计将包括通过电压传感器位点进行微刺激或在电化学位点施加极化电压的能力。正在进行的原型设计将得到进一步发展。将VLSI微电路集成到探针设计中，以实现更高的密度集成。 随着基本模块的完善，将开发多探头配置。研制了一种集成DSP的无线传输系统，以高速传输多路信息到主机。 将进一步开发一个采用Windows NT操作系统的双处理器主机PC工作站，并增强软件，以管理多通道数据流和分析。 将继续并扩大对学生的教育和对用户的培训。 与以前一样，将发展与小企业的互动，以传播技术开发的效用。 该项目将为许多NIH研究所（包括NIDA、NIA、NIAAA、NINDS和NIMH）的神经科学正在进行的研究和治疗需求提供关键技术。

The goal of this technology development program is to create a resource for fabrication and development of multichannel voltage and chemical sensor systems for the Neurosciences. The aim is to address the need to take advantage of new microcircuit fabrication techniques that have been recently developed within the Center for High Density Electronics at the U. Arkansas under direction of Dr. S. Ang. The plan is to work on four major aims in parallel. The first aim is to fabricate a new generation of small silicon-based multisite microprobes with sites specialized for either or both voltage or electrochemical sensing. Evaluation and study of sensor site properties will be conducted by Drs. I Fritsch (U. Ark.), D. Woodward (Wake Forest U.), and R.M. Wightman (U.N. Carolina). A second aim is to integrate the silicon probe into flexible polyimide cable system. New technologies for fabrication and coating of such materials will be adapted for in vivo Neuroscience applications. A third aim is to design and fabricate multichannel VLSI microchip headstage devices to amplify and transmit information from the voltage and electrochemcal sensor sites. The chip design will include the capacity to microstimulate through the voltage sensor sites or to apply polarization voltages at the electrochemical sites. Prototype designs already in progress will be developed further. The VLSI microcircuit will be integrated into the probe design to achieve higher desensity integration. A multiple probe configuration will be developed as the basic module is perfected. A wireless transmission system with an integrated DSP will be developed to digitize and transmit multichannel information at high rates to a host computer. A dual processor host PC workstation with the Windows NT Operating System will be further developed with software enhancements to manage the multichannel data flow and analysis. Education of students and training of users will be continued and expanded. As has been done previously, interactions with small businesses will be developed to disseminate utility of the technology development. This project will provide technology critical for ongoing research and therapeutic needs in Neuroscience of many NIH Institutes, including NIDA, NIA, NIAAA, NINDS, and NIMH.