FASEB Conference:Vitamin K&Synthesis,Structure,Function

描述（由申请人提供） 这一建议是为了部分支持维生素K和维生素C的会议。 K-依赖蛋白质，正在举行的联合会的赞助下， 美国科学家实验生物学（FASEB），2001年8月4日至9日，在 佛蒙特州萨克顿河的佛蒙特学院。本次会议将代表 多学科领域跨越营养，维生素K的应用， 干预骨质疏松症和心血管疾病，血液凝固， 骨骼发育和芋螺毒素Gla神经活性肽。基本 生物化学和分子机制提供了基础， 维生素K介导的生物活性的共同调节参数。 维生素K依赖性羧化酶的知识，结构要求 Gla肽底物和酶的相互作用，调节前肽和 成熟的蛋白质合成，维生素K的需求，以及 钙结合Gla结构域与磷脂膜成分， 将评价维生素K依赖性蛋白的共有性质。 会议将重点讨论维生素K研究的最新进展。 参加人数将限于150名申请人，他们将在 专业知识和能力的基础，以促进一个激励和富有成效的 会议会议将包括九个科学会议，两个下午 圆桌讨论和海报会议。会议的主要议题将是： (1)维生素K与营养;（2）维生素K的结构与功能关系 依赖蛋白质和膜相互作用，（3）分子机制 介导基因表达/维生素K依赖的发育调节 （4）基质Gla蛋白与组织功能;（5）基质Gla蛋白与组织功能; Gla蛋白与心血管疾病，（6）维生素K状况：骨骼 病理生理学的治疗干预，（7）玻璃芋螺毒素家族 神经肽和最近发现的含Gla的蛋白质，（8）家族 维生素K羧化酶，（9）维生素K和华法林。交流思想 这些来自不同领域的研究人员的见解将提供 新的科学合作和新的研究方向的机会， 对神经系统、心血管和骨骼疾病的潜在影响。的 该计划包括该领域的领导者和新的/初级调查员， 博士后研究员，来自欧洲和亚洲的科学家， 独特的发现

DESCRIPTION (provided by applicant) This proposal is for partial support of a conference on Vitamin K and Vitamin K-Dependent Proteins that is being held under the auspices of the Federation of American Scientists for Experimental Biology (FASEB) from August 4-9, 2001, at the Vermont Academy in Saxtons River, VT. This conference will represent multi-disciplinary fields spanning nutrition, application of vitamin K for intervention of osteoporosis and cardiovascular disorders, blood coagulation, skeletal development, and the conotoxin Gla neuroactive peptides. Fundamental biochemical and molecular mechanisms provide the basis for assimilating the common regulatory parameters of vitamin K mediated biological activity. Knowledge of the vitamin K dependent carboxylase, the structural requirements of Gla peptide substrate and enzyme interactions, regulation of propeptide and mature protein synthesis, the requirements for vitamin K, and interactions of calcium bound-Gla domains with phospholipid membrane components that reflect the shared properties of the vitamin K-dependent proteins will be evaluated. The meeting will focus on the most recent developments in vitamin K research. Participation will be limited to 150 applicants who will be selected on the basis of expertise and ability to contribute to a stimulating and productive meeting. The conference will consist of nine scientific sessions, two afternoon roundtable discussions, and poster sessions. The major session topics will be: (1) vitamin K and nutrition, (2) structure-function relationships of vitamin dependent proteins and membrane interactions, (3) molecular mechanisms mediating gen expression/developmental regulation of vitamin k dependent proteins with aging, (4) matrix Gla proteins and tissue functions, (5) matrix Gla proteins and cardiovascular disease, (6) vitamin K status: skeletal pathophysiologies an therapeutic intervention, (7) the Conotoxin family of Gla neuropeptides and recently discovered Gla containing proteins, (8) the family of vitamin K carboxylase enzymes, (9) vitamin K and warfarin. Exchange of ideas and insights among these investigators from diverse fields will provide the opportunity for new scientific collaboration and new research directions with potential for impact on neurologic, cardiovascular and bone diseases. The program includes leaders in the field and new/junior investigators, postdoctoral fellows, and scientists from Europe and Asia with exciting and unique findings.