Pilot Projects Program
试点项目计划
基本信息
- 批准号:10205091
- 负责人:
- 金额:$ 50.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-03 至 2022-08-04
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAddressApplications GrantsAwardBasic ScienceBiostatistics CoreCardiovascular DiseasesCardiovascular systemClinicalClinical ResearchClinical Research ProtocolsClinical TrialsCollaborationsCommunitiesCommunity PracticeCommunity SurveysCustomDevelopmentDiabetes MellitusDisciplineDiseaseEducational ActivitiesEpidemiologyEvaluationExtramural ActivitiesFosteringFundingGoalsGrantGroup MeetingsGrowthHealthHealthcareIACUCIncentivesInstitutionInstitutional Review BoardsInterventionInvestigationLaboratory ScientistsLeadershipMaineMalignant NeoplasmsManuscriptsMeasuresMedical centerMethodsMissionMonitorNew EnglandObesityOutcomePatientsPerformancePhysiciansPilot ProjectsPopulationPractice based researchPreparationPreventionProblem SolvingProgram Research Project GrantsProviderPublicationsPublishingResearchResearch DesignResearch PersonnelResearch Project GrantsResourcesRoleRuralRural CommunityRural HealthRural PopulationScientistSecureSubstance abuse problemSustainable DevelopmentTechnologyTrainingTranslational ResearchUniversitiesUpdateVermontWorkaddictionbarrier to carebasecareer developmentcatalystdesignexperiencehealth care deliveryimprovedinnovationinterdisciplinary collaborationmeetingsmembermultidisciplinarynovelpatient oriented researchpreventprogramsrecruitrural arearural dwellersskillssuccesstraining opportunitytranslational approachtranslational research programtranslational studyweb site
项目摘要
PROJECT SUMMARY
The Pilot Project Program (PPP) of the NNE-CTR is a critical pipeline for clinical and translational research,
and for investigators who will develop translational research programs that foster the multidirectional and
transdisciplinary interactions necessary for patient-oriented research. The PPP is designed to stimulate new
collaborations and multidisciplinary partnerships between researchers and rural clinicians, in order to address
the disease-specific needs of the population of Northern New England. The PPP will emphasize collaborations
and maximize interactions between Maine Medical Center (MMC) and University of Vermont (UVM)
researchers and community- and rural-based clinicians to conduct research that will prevent and improve
treatment of diseases that are prevalent in Northern New England. We will engage laboratory scientists,
physician investigators and rural practitioners to collaborate on the investigation of cancer, cardiovascular and
related diseases (e.g., obesity, diabetes) and substance abuse disorders, among others. This mission will be
accomplished by the following specific aims: 1) Recruit investigators and facilitate the formation of
interdisciplinary teams to conduct translational research addressing the health needs of the region. Research
catalysts will provide guidance to rural practitioners and others new to the research endeavor. 2) Assure the
success of the Pilot Project Program by providing investigators with the unique resources, skill sets and
capabilities available through the NNE-CTR Cores, including “Studio sessions” with Key Component Activity
(KCA) Directors, research catalysts, content experts, and community members to optimize study design and
maximize study impact; access the educational activities of the Professional Development Core to build skills;
provide “active surveillance” of ongoing pilot project studies to solve problems as they arise; and provide
Scholar Awards for specific customized training opportunities in clinical and translational approaches to further
enhance our investigators' success. 3) Continuously assess the “value added” by the Pilot Projects to the
NNE-CTR using traditional and innovative metrics. PPP Directors will work with the NNE-CTR Leadership to
evaluate success and further optimize our approach. Mixed methods results from the Tracking and Evaluation
KCA will provide critical information necessary to refine our approach and assure that the PPP is providing the
highest value to our community of investigators, clinicians and importantly to the residents of rural New
England. Innovative findings from NNE-CTR pilot studies could develop into larger clinical studies and attract
independent funding that could impact treatment paradigms.
项目摘要
NNE-CTR的试点项目计划(PPP)是临床和转化研究的关键管道,
和研究人员谁将开发转化研究计划,促进多方向,
以病人为导向的研究所需的跨学科互动。PPP旨在刺激新的
研究人员和农村临床医生之间的合作和多学科伙伴关系,以解决
北方新英格兰人口的疾病特异性需求。PPP将强调合作
并最大限度地发挥缅因州医学中心(MMC)和佛蒙特大学(UVM)之间的互动
研究人员和社区和农村为基础的临床医生进行研究,将预防和改善
治疗北方新英格兰流行的疾病。我们会让实验室的科学家,
医生调查人员和农村从业人员合作调查癌症,心血管和
相关疾病(例如,肥胖症、糖尿病)和药物滥用障碍等。这次使命
通过以下具体目标实现:1)招募调查员并促进
跨学科团队进行转化研究,以满足该地区的健康需求。研究
催化剂将为农村从业人员和其他新的研究工作提供指导。2)保证
通过为研究者提供独特的资源、技能组合和
通过NNE-CTR核心提供的功能,包括具有关键组件活动的"Studio会话"
(KCA)董事,研究催化剂,内容专家和社区成员,以优化研究设计和
最大限度地提高学习效果;访问专业发展核心的教育活动,以培养技能;
对正在进行的试点项目研究进行"积极监督",以解决出现的问题;
学者奖,用于临床和转化方法的特定定制培训机会,以进一步
提高我们调查人员的成功率3)不断评估试点项目对
NNE-CTR使用传统和创新的指标。PPP董事将与NNE-CTR领导层合作,
评估成功并进一步优化我们的方法。跟踪和评价的混合方法结果
KCA将提供必要的关键信息,以完善我们的方法,并确保PPP提供
最高的价值,我们的社区的调查人员,临床医生,重要的是农村居民的新
英格兰NNE-CTR试点研究的创新发现可以发展为更大的临床研究,并吸引
独立的资金,可能会影响治疗模式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jane B. Lian其他文献
Networks and hubs for the transcriptional control of osteoblastogenesis
- DOI:
10.1007/s11154-006-9001-5 - 发表时间:
2006-06-01 - 期刊:
- 影响因子:8.000
- 作者:
Jane B. Lian;Gary S. Stein;Amjad Javed;Andre J. van Wijnen;Janet L. Stein;Martin Montecino;Mohammad Q. Hassan;Tripti Gaur;Christopher J. Lengner;Daniel W. Young - 通讯作者:
Daniel W. Young
Gamma-carboxyglutamate excretion and calcinosis in juvenile dermatomyositis.
幼年皮肌炎中的γ-羧基谷氨酸排泄和钙质沉着。
- DOI:
10.1002/art.1780250910 - 发表时间:
1982 - 期刊:
- 影响因子:0
- 作者:
Jane B. Lian;Jane B. Lian;Lauren M. Pachman;C. Gundberg;Raymond E. H. Partridge;M. Maryjowski - 通讯作者:
M. Maryjowski
LB-036 - Cbfβ prevents articular cartilage degeneration
- DOI:
10.1016/j.joca.2024.03.038 - 发表时间:
2024-06-01 - 期刊:
- 影响因子:
- 作者:
Xiangguo Che;Xian Jin;Dong-Kyo Lee;Hee-June Kim;Hee-Soo Kyung;Hyun-Ju Kim;Jane B. Lian;Janet L. Stein;Gary S. Stein;Je-Yong Choi - 通讯作者:
Je-Yong Choi
Mitotic bookmarking of genes: a novel dimension to epigenetic control
基因的有丝分裂书签:表观遗传控制的一个新维度
- DOI:
10.1038/nrg2827 - 发表时间:
2010-07-13 - 期刊:
- 影响因子:52.000
- 作者:
Sayyed K. Zaidi;Daniel W. Young;Martin A. Montecino;Jane B. Lian;Andre J. van Wijnen;Janet L. Stein;Gary S. Stein - 通讯作者:
Gary S. Stein
Nuclear microenvironments in biological control and cancer
生物防治和癌症中的核微环境
- DOI:
10.1038/nrc2149 - 发表时间:
2007-06-01 - 期刊:
- 影响因子:66.800
- 作者:
Sayyed K. Zaidi;Daniel W. Young;Amjad Javed;Jitesh Pratap;Martin Montecino;Andre van Wijnen;Jane B. Lian;Janet L. Stein;Gary S. Stein - 通讯作者:
Gary S. Stein
Jane B. Lian的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jane B. Lian', 18)}}的其他基金
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
项目 3:MANCR 介导晚期乳腺癌生存的表观遗传机制
- 批准号:
10380073 - 财政年份:2021
- 资助金额:
$ 50.31万 - 项目类别:
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
项目 3:MANCR 介导晚期乳腺癌生存的表观遗传机制
- 批准号:
10608059 - 财政年份:2021
- 资助金额:
$ 50.31万 - 项目类别:
Runx2 Organizes Transcriptional Complexes in Nuclear Microenvironments to Support
Runx2 在核微环境中组织转录复合物以支持
- 批准号:
8601049 - 财政年份:2013
- 资助金额:
$ 50.31万 - 项目类别:
Runx2 Organizes Transcriptional Complexes in Nuclear Microenvironments to Support
Runx2 在核微环境中组织转录复合物以支持
- 批准号:
8052327 - 财政年份:2011
- 资助金额:
$ 50.31万 - 项目类别:
RUNX@ Subnuclear Targeting Integrates Signaling Pathways for Bone Formation
RUNX@ 亚核靶向整合骨形成信号通路
- 批准号:
8289359 - 财政年份:2011
- 资助金额:
$ 50.31万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 50.31万 - 项目类别:
Research Grant














{{item.name}}会员




