9th International Gastric Proton Transport Conference

第九届国际胃质子传输会议

• 批准号: 6370788
• 负责人: JOHN G FORTE
• 金额: $ 1.1万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6370788
• 关键词: gastrointestinal absorption /transport; ion transport; meeting /conference /symposium; travel

This proposal requests funds in partial support of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Gastric Proton Transport ", to be held August 19-21, 2001, in Leura, Australia. This is the 9th in a series that has met in association with the Congress of the International Union of Physiological Sciences every 3 to 4 years since 1971. Previous meetings have been distinguished by success in achieving objectives to promote (1) the exceptional progression of discoveries in gastric secretory physiology and pharmacology over the past 30 years, and (2) effective cross fertilization of research through interaction with outstanding scientists working outside the gastric field. Published proceedings of previous meetings attest to these successes as does reported enthusiasm of participants at all levels of training and experience. The Organizing Committee for the Conference is composed of notable contributors to gastric secretory physiology as well as three former Conference chairs, including: Drs. Catherine S. Chew, Gunnar Flemstrom, John G. Forte, James R. Goldenring, Barry Hirst, George Sachs, Tetsuro Urushidani (Secretariat). The Committee developed the program and will act as referees in selecting contributed abstracts for presentation and travel awards to young investigators. There have been major advances in the molecular biology of the gastric proton pump, the regulation of cellular secretory function, and the modulation of gastric pathophysiology by a variety of drugs. The principal objectives of the Conference are to discuss the implications of these findings, to enrich their efforts with presentations by scholars in closely related fields, and to develop strategies for future research and targets for pharmacological intervention. We now know that Helicobacter pylori plays a central role in the pathogenesis of peptic ulcer disease. This has not minimized the role of gastric acid but rather has directed focus on the synergism of injurious factors for the disease. Toward these goals the slate of topics will attract a broad audience of participation and focus current issues in the field, including (1) structure and function of H,K-ATPase - molecular basis as a drug target; (2) Helicobacter pylori - molecular microbiology and strategy for eradication; (3) gene targeting studies in the mouse - mechanisms of acid secretion and cell proliferation; (4) signal transduction in the parietal cell - pathway to activation; (5) cytoskeleton & membrane trafficking - the gastric parietal cell as a model for membrane recruitment.

该提案请求资金部分支持将于 2001 年 8 月 19 日至 21 日在澳大利亚鲁拉举行的第九届国际质子传输会议“胃质子传输的机制和后果”。这是自 1971 年以来每 3 至 4 年与国际生理科学联合会大会联合召开的系列会议中的第 9 次。以前的会议以成功实现以下目标而著称：(1) 过去 30 年来胃分泌生理学和药理学发现的特殊进展；(2) 通过与胃领域以外的杰出科学家互动，有效地促进研究的交叉发展。已发表的以往会议记录证明了这些成功，各级别培训和经验的参与者的热情也证明了这些成功。会议组织委员会由胃分泌生理学的著名贡献者以及三名前会议主席组成，包括： Drs. Catherine S. Chew、Gunnar Flemstrom、John G. Forte、James R. Goldenring、Barry Hirst、George Sachs、Tetsuro Urushidani（秘书处）。该委员会制定了该计划，并将充当裁判员，选择提交的摘要进行演示，并为年轻研究人员提供旅行奖励。胃质子泵的分子生物学、细胞分泌功能的调节以及多种药物对胃病理生理学的调节已经取得了重大进展。会议的主要目标是讨论这些发现的影响，通过密切相关领域的学者的演讲来丰富他们的努力，并制定未来研究的策略和药理学干预的目标。我们现在知道幽门螺杆菌在消化性溃疡病的发病机制中起着核心作用。这并没有最小化胃酸的作用，而是将注意力集中在疾病的有害因素的协同作用上。为了实现这些目标，一系列主题将吸引广泛的受众参与并关注该领域当前的问题，包括（1）H,K-ATP酶的结构和功能——作为药物靶点的分子基础； (2) 幽门螺杆菌-分子微生物学和根除策略； (3) 小鼠基因靶向研究——酸分泌和细胞增殖机制； (4) 壁细胞中的信号转导——激活途径； (5) 细胞骨架和膜运输——胃壁细胞作为膜招募的模型。