9th International Gastric Proton Transport Conference

这项提案请求提供资金，以部分支持将于2001年8月19日至21日在澳大利亚勒拉举行的第九届国际质子运输大会“胃质子运输的机制和后果”。这是自1971年以来每隔3至4年召开一次国际生理科学联合会大会的系列会议中的第9次。以前的会议的特点是成功地实现了以下目标：(1)过去30年来胃分泌生理学和药理学的发现取得了非凡的进展，(2)通过与胃领域外工作的杰出科学家的互动，有效地促进了研究的交叉受精。公布的以往会议记录证明了这些成功，报告的各级培训和经验参与者的热情也证明了这些成功。会议组委会由胃分泌生理学的著名贡献者和三位前会议主席组成，其中包括：Catherine S.Chew博士、Gunnar Flemstrom博士、John G.Forte博士、James R.Goldenring博士、Barry Hirst博士、George Sachs博士、Tetsuro Urusshiani博士(秘书处)。该委员会制定了该计划，并将担任评审员，挑选提交的摘要，并向年轻研究人员颁发旅行奖。近年来，在胃质子泵的分子生物学、细胞分泌功能的调节以及多种药物对胃的病理生理调控等方面取得了重大进展。会议的主要目标是讨论这些发现的影响，通过密切相关领域的学者的陈述来丰富他们的努力，并为未来的研究制定战略和药理学干预的目标。我们现在知道幽门螺杆菌在消化性溃疡的发病机制中起着核心作用。这并没有减少胃酸的作用，而是将重点放在了损伤因素对疾病的协同作用上。为了实现这些目标，这一系列专题将吸引广大受众的参与，并聚焦该领域当前的问题，包括(1)H，K-ATPase的结构和功能--作为药物靶标的分子基础；(2)幽门螺杆菌--分子微生物学和根除策略；(3)基因靶向研究--小鼠体内的酸分泌和细胞增殖机制；(4)壁细胞中的信号转导--激活的途径；(5)细胞骨架与膜运输--作为膜招募模型的胃壁细胞。

This proposal requests funds in partial support of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Gastric Proton Transport ", to be held August 19-21, 2001, in Leura, Australia. This is the 9th in a series that has met in association with the Congress of the International Union of Physiological Sciences every 3 to 4 years since 1971. Previous meetings have been distinguished by success in achieving objectives to promote (1) the exceptional progression of discoveries in gastric secretory physiology and pharmacology over the past 30 years, and (2) effective cross fertilization of research through interaction with outstanding scientists working outside the gastric field. Published proceedings of previous meetings attest to these successes as does reported enthusiasm of participants at all levels of training and experience. The Organizing Committee for the Conference is composed of notable contributors to gastric secretory physiology as well as three former Conference chairs, including: Drs. Catherine S. Chew, Gunnar Flemstrom, John G. Forte, James R. Goldenring, Barry Hirst, George Sachs, Tetsuro Urushidani (Secretariat). The Committee developed the program and will act as referees in selecting contributed abstracts for presentation and travel awards to young investigators. There have been major advances in the molecular biology of the gastric proton pump, the regulation of cellular secretory function, and the modulation of gastric pathophysiology by a variety of drugs. The principal objectives of the Conference are to discuss the implications of these findings, to enrich their efforts with presentations by scholars in closely related fields, and to develop strategies for future research and targets for pharmacological intervention. We now know that Helicobacter pylori plays a central role in the pathogenesis of peptic ulcer disease. This has not minimized the role of gastric acid but rather has directed focus on the synergism of injurious factors for the disease. Toward these goals the slate of topics will attract a broad audience of participation and focus current issues in the field, including (1) structure and function of H,K-ATPase - molecular basis as a drug target; (2) Helicobacter pylori - molecular microbiology and strategy for eradication; (3) gene targeting studies in the mouse - mechanisms of acid secretion and cell proliferation; (4) signal transduction in the parietal cell - pathway to activation; (5) cytoskeleton & membrane trafficking - the gastric parietal cell as a model for membrane recruitment.