CONFERENCE ON DENDRITIC CELLS

描述：（改编自申请人的摘要）树突状细胞（DC）是 被认为是免疫系统的关键控制者，包括免疫 临床医学方面。 DC生物学继续发展， 令人惊讶的方式。 存在具有不同功能的新的DC子集; 控制免疫启动的新的成熟刺激物; 可视化淋巴组织和病理状态中的DC;新分子 控制DC迁移和寿命的机制;以及旨在 操控特区的生理机能 因此，直接投入一个 整个会议都是DC自己的。 然而，另外重要的是， 强调DC生物学的发展，与其他活跃的 地区 免疫生物学 和医药 主要 接口 这 多学科 会议包括 第一章 细胞 生物学 抗原 呈递，包括细胞内MHC II的调节功能 区室，用于呈递MHC I类的外源性途径，以及 非经典呈递分子如CD 1; 2）T细胞共刺激，包括 MHC和辅助分子的聚集形成免疫原性 突触; 3）DC在调节T细胞功能中的作用，包括 Thl/Th 2亚群、调节性T细胞和外周耐受性; 4）Thl/Th 2亚群、调节性T细胞和外周耐受性; 感染因子与DC的相互作用，包括新兴病毒载体 用于表达重组基因;和5）人免疫疗法，使用DC作为 佐剂会议将突出年轻科学家的参与 通过增加新调查人员的更长时间的会谈，缩短 从摘要中选出的演讲，以及几个关键领域的研讨会。 地区该计划和参与的广度将使这次会议成为一个 必须为许多学生和博士后谁现在提供的进步， 该领域

DESCRIPTION: (Adapted from Applicant s Abstract) Dendritic cells (DCs) are recognized as the key controllers of the immune system, including immune aspects of clinical medicine. DC biology continues to develop in significant and surprising ways. There are new subsets of DCs with different functions; new maturation stimuli that control the initiation of immunity; new markers to visualize DCs in lymphoid tissues and pathologic states; new molecular mechanisms that control DC migration and lifespan; and new therapies aimed at manipulating DC physiology. Therefore, it is straightforward to devote an entire meeting to DCs themselves. However, it is additionally important to emphasize the developments in DC biology that interface with other active areas of immunobiology and medicine. The main interfaces of this multidisciplinary meeting comprise 1) the cell biology of antigen presentation, including the regulated function of intracellular MHC II compartments, the exogenous pathway for presentation on MHC class I, and nonclassical presenting molecules like CD1; 2) T cell costimulation, including the clustering of MHC and accessory molecules to form the immunological synapse; 3) the role of DCs in the regulation of T cell function, including Thl/Th2 subsets, regulatory T cells, and peripheral tolerance; 4) the interaction of infectious agents with DCs, including emerging viral vectors for expression of recombinant genes; and 5) human immunotherapy, using DCs as adjuvants. The meeting will highlight the participation of younger scientists through the inclusion of longer talks by rising new investigators, shorter presentations selected from the abstracts, and several workshops in critical areas. The program and the breadth of participation will make this meeting a must for the many students and postdocs who are now providing the advances in this field.