Dendritic Cells: Interfaces with Immunobiology/Medicine

树突状细胞：与免疫生物学/医学的接口

• 批准号: 6583501
• 负责人: Ralph Marvin Steinman
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-15 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6583501
• 关键词: dendritic cells; immunology; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): Dendritic cells control the immune system from different vantage points. Dendritic cells control the responses of several types of lymphocytes; the transition between innate and adaptive immunity; the quality of the T cell response including Th1 polarization, memory, and even tolerance; and immunology in many clinical settings. This multidisciplinary meeting will develop the following areas: 1) vaccination and immune therapy, including the manipulation of dendritic cell function in vivo; 2) interactions of dendritic cells with microbial pathogens including the many innate functions of dendritic cells; 3) the early response of different types of lymphocytes to dendritic cells, and the organization of this response in vivo; 4) the role of dendritic cells in different forms of peripheral tolerance and the regulation of autoimmunity; 5) the specialized properties of dendritic cells in antigen handling, processing and presentation. As has been the case in prior Keystone Symposia on dendritic cells, there will be an equal number of presentations by invited speakers and speakers selected from the abstracts. The organizers have planned two coordinate meetings, the first entitled Dendritic Cells, Interfaces with Immunobiology & Medicine (March 5-10, 2003), and the second Cell Biology of the Immune Response (March 7-12, 2003). Each will be a four-day meeting, but will share joint sessions on the two overlapping days. This will provide an opportunity to bring together scientists interested in a valuable range of topics in immunology in general and dendritic cells in particular.

描述（由申请人提供）：树突状细胞从不同的有利位置控制免疫系统。树突状细胞控制几种类型淋巴细胞的反应；先天免疫与适应性免疫的过渡；T细胞反应的质量，包括Th1极化、记忆甚至耐受；以及免疫学在许多临床环境中的应用。本次多学科会议将发展以下领域：1)疫苗接种和免疫治疗，包括体内树突状细胞功能的操纵；2)树突状细胞与微生物病原体的相互作用，包括树突状细胞的许多先天功能；3)不同类型淋巴细胞对树突状细胞的早期反应，以及这种反应在体内的组织；4)树突状细胞在不同形式外周耐受和自身免疫调节中的作用；5)树突状细胞在抗原处理、加工和呈递中的特殊特性。就像之前关于树突细胞的Keystone专题讨论会一样，邀请的演讲者和从摘要中挑选的演讲者将会有相同数量的演讲。组织者计划了两次协调会议，第一次题为“树突状细胞，与免疫生物学和医学的接口”（2003年3月5日至10日），第二次题为“免疫反应细胞生物学”（2003年3月7日至12日）。每次会议为期四天，但将在重叠的两天举行联席会议。这将提供一个机会，把对免疫学和树突状细胞的一系列有价值的主题感兴趣的科学家聚集在一起。