A WORKSHOP: POOLED ANALYSIS OF LEAD-EXPOSED COHORTS

描述(摘自调查人员摘要) 这个拟议的研讨会将召集16名调查人员，代表7名 9月23日举行的一次会议的国际预期铅暴露队列， 2000进行综合分析并检查与铅相关的认知 赤字低于每分升10微克(微克/分升)。优势性 实验和人体数据表明，有持久性的、有害的 低水平铅暴露对大脑功能的影响，如 智慧。有证据表明，认知缺陷与铅有关 暴露在10微克/分升以下，但血铅浓度最低 与不良认知影响相关的因素尚未定义。每一位 前瞻性研究纳入的儿童太少，无法检查任何不良反应 血铅浓度的影响&10微克/分升。然而，总体而言，有 包括在7个预期队列中的1500多名儿童接受了检查 在汇集分析中。这一拟议研讨会的目标和分析 是测试与血铅相关的认知缺陷的证据 浓度低于10mcg/dl，通过汇集现有的预期队列。这个 会议将：1.回顾现有的科学文献，表明 血铅浓度低于10的铅相关认知缺陷 Mcg/dl。2.检测血铅浓度与智商的关系(总分， 口头和表演)适用于所有儿童和有血铅的人 浓度为&lt；10微克/dl、&lt；5微克/dl和&lt；2.5微克/dl。 研讨会将与第18届国际 在科罗拉多州斯普林斯举行的神经毒理学会议。主办方将 细化分析策略以执行集合分析，制定 关于包含变量的共识，并定义用于比较的变量 不同的研究。如果拟议分析的结果表明 与铅相关的认知障碍发生在10微克/分升以下，它将提供 支持降低血铅水平的证据 “可接受”--从10 mg/dl到5 mg/dl或更低。它还会主张建立一个 转向儿童铅暴露的一级预防，这是 与目前几乎完全依赖案例的努力形成鲜明对比 血铅水平升高的儿童的管理。

DESCRIPTION (Taken from the Investigator's Abstract) This proposed workshop is to convene 16 investigators representing 7 international, prospective lead-exposed cohorts for a meeting on September 23, 2000 to conduct a pooled analysis and examine lead-associated cognitive deficits below 10 micrograms per deciliter (mcg/dl). The preponderance of experimental and human data indicate that there are persistent, deleterious effects of low-level lead exposure on brain function, such as diminished intelligence. There is evidence that cognitive deficits associated with lead exposure occur below 10 mcg/dl, but the lowest blood lead concentration associated with adverse cognitive effects had not been defined. Each of the prospective studies have included too few children to examine any adverse effects of blood lead concentration < 10 mcg/dl. Collectively, however, there are over 1,500 children examined in the 7 prospective cohorts to be included in the pooled analyses. The objective of this proposed workshop and analyses is to test for evidence of cognitive deficits associated with blood lead concentrations below 10mcg/dl by pooling existing prospective cohorts. The conference will: 1. Review existing scientific literature that indicates lead-associated cognitive defects at blood lead concentrations below 10 mcg/dl. 2. Examine the relation of blood lead concentration and IQ (total, verbal and performance) for all children and for those who have blood lead concentrations at < 10 mcg/dl, < 5 mcg/dl, and < 2.5 mcg/dl. The workshop will be held in conjunction with the 18th International Neurotoxicology Conference in Colorado Springs, CO. The organizers will refine an analytic strategy to conduct the pooled analysis, develop a consensus about inclusion of variables, and define variables for comparison across studies. If the results of the proposed analyses show that lead-related cognitive deficits occur below 10 mcg/dl, it will provide evidence that argues for a reduction in blood lead levels considered "acceptable" - from 10mg/dl to 5mg/dl or lower. It would also argue for a shift toward the primary prevention of childhood lead exposure, which contrasts sharply with current efforts that rely almost exclusively on case management of children with elevated blood lead levels.