ALTERATION OF GENE REGULATION BY ENVIRONMENTAL COMPOUNDS

路易斯安那州泽维尔大学将领导一个由来自泽维尔大学和杜兰大学的研究人员组成的合作项目。该方案的目标是增加泽维尔大学研究人员对环境卫生科学竞争性研究的参与，这些研究主要由NIEHS资助，一般由NIH资助。为了实现这一目标，这项ARCH拨款的具体目标有四个方面：(1)在泽维尔大学和杜兰大学的科学家之间建立多学科研究合作，以建立和维持不断增加的环境健康科学研究能力。两项研究和四项试点项目将研究环境化合物对核类固醇激素受体转录调节、人类DNA重排和突变以及金属硫蛋白的影响。每个项目包括来自每个机构的研究人员之间的合作。(2)为教员组织并举办正式的助学金课程。本学期课程的目标是让每位参与者创建、编辑并向NIEHS或NIH的竞争性主流项目提交一份研究计划。完成这个拨款写作课程对于接受ARCH资助的泽维尔大学调查是强制性的。(3)在泽维尔大学建立核心设施，以支持当前和未来的环境健康科学研究项目。将建立的三个核心设施是(i)组织培养实验室，（ii）环境分子生物学实验室和（iii）分子相互作用实验室。(4)招聘一名有竞争力获得校外主流NIEHS或NIH支持的新教员。ARCH项目将建立在泽维尔大学和杜兰大学在环境研究方面长达十年的合作关系的基础上，以加强教师层面的积极合作关系。预计由ARCH项目专门提供的指导和指导将为泽维尔大学的教师准备和提交有竞争力的资助提案提供必要的基础设施，以实现独立于ARCH项目的目标。

Xavier University of Louisiana will lead a collaborative program project comprised of investigators from Xavier and Tulane Universities. The goal of this program is to increase the participation of investigators at Xavier University in competitive environmental health sciences research funded by the NIEHS in particular and the NIH in general. Toward that end, the specific aims for this ARCH grant are four-fold: (1) To establish a multi- disciplinary research collaboration among scientists at Xavier and Tulane to build and sustain an increased capacity for environmental health sciences research. Two Research and four Pilot Projects will study the effects of environmental compounds on the regulation of transcription by nuclear steroid hormone receptors, the rearrangement and mutation of human DNA, and metallothionein. Each project comprises a collaboration among investigators from each institution. (2) To assemble and conduct a formal course on grantsmanship for faculty. The objective of this semester-long course will be for each participant to create, edit, and submit a research proposal to a competitive mainstream program in the NIEHS or NIH. Completion of this grant writing course will be mandatory for Xavier investigations who receive ARCH funding. (3) To establish core facilities at Xavier to support current and future research programs in the environmental health sciences. Three core facilities to be established are (i) a tissue culture laboratory, (ii) an environmental molecular biology laboratory, and (iii) a molecular interaction laboratory. (4) To recruit and hire a new faculty member who will be competitive in obtaining extramural mainstream NIEHS or NIH support. The ARCH program will build upon the established, decade-old cooperative relationship between Xavier and Tulane in environmental research to strengthen a vigorous partnership at the faculty level. It is anticipated that the mentoring and instruction provided specifically by the ARCH program will provide the infrastructure necessary for Xavier faculty to prepare and submit competitive grant proposals to achieve independence from the ARCH program.