ALTERATION OF GENE REGULATION BY ENVIRONMENTAL COMPOUNDS

路易斯安那州泽维尔大学将领导一个由泽维尔大学和杜兰大学的研究人员组成的合作项目。该计划的目标是增加泽维尔大学研究人员对由NIEHS和NIH资助的竞争性环境健康科学研究的参与。为此，这笔ARCH赠款的具体目标有四个：(1)在泽维尔和杜兰的科学家之间建立一个多学科的研究合作，以建立和维持提高环境健康科学研究的能力。两项研究和四个试点项目将研究环境化合物对核类固醇激素受体、人类DNA重排和突变以及金属硫蛋白转录调控的影响。每个项目都包括每个机构的调查人员之间的合作。(2)为教职员筹办一项有关授勋精神的正式课程。这门为期一学期的课程的目标将是让每个参与者创建、编辑并向NIEHS或NIH的一个有竞争力的主流项目提交一份研究提案。对于接受ARCH资助的泽维尔调查来说，完成这一赠款写作课程将是强制性的。(3)在泽维尔建立核心设施，以支持当前和未来的环境健康科学研究计划。将建立的三个核心设施是(I)组织培养实验室、(Ii)环境分子生物学实验室和(Iii)分子相互作用实验室。(4)招聘和聘用一名在获得校外主流NIEHS或NIH支持方面具有竞争力的新教员。ARCH计划将建立在泽维尔和杜兰在环境研究方面已建立的长达十年的合作关系的基础上，以加强教职员工层面的强有力的合作伙伴关系。预计ARCH方案专门提供的指导和指导将为泽维尔教员准备和提交具有竞争力的拨款提案提供必要的基础设施，以实现与ARCH方案的独立。

Xavier University of Louisiana will lead a collaborative program project comprised of investigators from Xavier and Tulane Universities. The goal of this program is to increase the participation of investigators at Xavier University in competitive environmental health sciences research funded by the NIEHS in particular and the NIH in general. Toward that end, the specific aims for this ARCH grant are four-fold: (1) To establish a multi- disciplinary research collaboration among scientists at Xavier and Tulane to build and sustain an increased capacity for environmental health sciences research. Two Research and four Pilot Projects will study the effects of environmental compounds on the regulation of transcription by nuclear steroid hormone receptors, the rearrangement and mutation of human DNA, and metallothionein. Each project comprises a collaboration among investigators from each institution. (2) To assemble and conduct a formal course on grantsmanship for faculty. The objective of this semester-long course will be for each participant to create, edit, and submit a research proposal to a competitive mainstream program in the NIEHS or NIH. Completion of this grant writing course will be mandatory for Xavier investigations who receive ARCH funding. (3) To establish core facilities at Xavier to support current and future research programs in the environmental health sciences. Three core facilities to be established are (i) a tissue culture laboratory, (ii) an environmental molecular biology laboratory, and (iii) a molecular interaction laboratory. (4) To recruit and hire a new faculty member who will be competitive in obtaining extramural mainstream NIEHS or NIH support. The ARCH program will build upon the established, decade-old cooperative relationship between Xavier and Tulane in environmental research to strengthen a vigorous partnership at the faculty level. It is anticipated that the mentoring and instruction provided specifically by the ARCH program will provide the infrastructure necessary for Xavier faculty to prepare and submit competitive grant proposals to achieve independence from the ARCH program.