Toward sustainable diesel production using microbial cells: unravelling isoprenoid pathway regulation through systems biology

利用微生物细胞实现可持续柴油生产：通过系统生物学揭示类异戊二烯途径调节

• 批准号: DP140103514
• 负责人: Prof Lars Nielsen
• 金额: $ 26.28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140103514
• 关键词: Toward; sustainable; diesel; production; using

The methylerythritol pyrophosphate (MEP) pathway for isoprenoid production is an essential biochemical pathway. It was only fully elucidated a decade ago, and the regulatory controls over this pathway are not understood. The objective of this project is to elucidate the mechanisms by which the MEP pathway is controlled in E. coli using a novel systems biology approach. Understanding control of the MEP pathway is required to gain insight into homeostatic control of this essential pathway, and enable biotechnological engineering of E. coli in order to produce a wide range of industrially useful isoprenoids (including biofuels, pharmaceuticals, industrial chemicals, neutraceuticals, food additives, perfumes and many more).

焦磷酸甲酯（MEP）途径是类异戊二烯产生的重要生化途径。它仅在十年前才被完全阐明，并且对该途径的调节控制尚不清楚。本研究的目的是阐明E.大肠杆菌中的一种新的系统生物学方法。了解MEP通路的控制是深入了解这一重要通路的稳态控制所必需的，并使E.大肠杆菌，以生产广泛的工业上有用的类异戊二烯（包括生物燃料、药物、工业化学品、营养品、食品添加剂、香料等等）。