FUNCTIONAL MAPPING OF COCAINE CRAVING, ACTIVATION AND WITHDRAWAL

该计划项目的总体目标是使用功能性磁共振成像（fMRI）作为主要工具，制作一个可解释的人类可卡因作用的大脑地图。 在项目1中，我们测试了以下假设：可卡因对大脑的影响与其强化特性和早期可卡因后烦躁不安有关，可以通过fMRI信号的改变来特异性地成像;可卡因依赖将改变随后可卡因给药激活大脑的方式;人类对可卡因渴望的功能解剖学将反映可卡因直接激活的一部分区域的激活。我们选择开发功能性磁共振成像技术来研究可卡因作用的人类神经生物学，因为受试者不会暴露于电离辐射或注射放射性物质，使得纵向研究可行，并且因为功能性磁共振成像提供了比其他可用的断层成像技术更好的空间（亚毫米）和时间（10赫兹）分辨率。

The overall goal of this Program Project is to produce an interpretable brain map of cocaine action in human beings using functional magneticresonance imaging (fMRI) as a principal tool. In Project 1, we test the hypothese that the effects of cocaine on the brain relevant to its reinforcing properties and to early post-cocaine dysphoria can be specifically imaged by alterations in fMRI signal; that cocaine dependence will alter the way in which subsequent cocaine administration activates the brain; and that the functional anatomy of human cocaine craving will reflect activation of a subset of the regions activated directly by cocaine. We have chosen to develop fMRI technology to study the human neurobiology of cocaine action because subjects will not be exposed to ionizing radiation or injected constrast material making longitudinal studies feasible, and because fMRI offers better spatial (sub-millimeter) and temporal (10 Hertz) resolution than other available tomographic imaging techniques.