INFANT HEME CATABOLISM AND CARBON MONOXIDE DETECTION

我们继续开发一氧化碳（CO）监测技术，用于实验室和床边诊断由其他原因引起的总胆红素产生增加的溶血。这包括开发和改进测量排出一氧化碳的仪器和技术。这些努力与加州圣卡洛斯的Natus医疗公司合作，已经生产出一种便携式无创仪器，用于床边监测潮汐末呼吸一氧化碳，作为所有原因的胆红素产生的指标。近年来，高强度发光二极管（led）作为一种可能的光治疗高胆红素血症的研究。这些节能、低发热的光源有可能在可见光光谱的蓝绿部分提供窄波长带的高强度光，这与胆红素的吸收光谱重叠。

We continue our development of carbon monoxide (CO)-monitoring technology for laboratory and bedside diagnosis of hemolysis of increased total bilirubin production from other causes. This involves developing and refining instrumentation and techniques for the measurement of excreted CO. These efforts with the cooperation of Natus Medical Inc., San Carlos CA, have resulted in the production of a portable non-invasive instrument for the bed-side monitoring of end-tidal breath CO as an index of bilirubin production for all causes. Recently, high intensity light-emitting diodes (LEDS) have been studied as a possible light for phototherapy of hyperbilirubinemia. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin.