INFANT HEME CATABOLISM AND CARBON MONOXIDE DETECTION

我们继续开发一氧化碳（CO）监测技术，用于实验室和床旁诊断其他原因引起的总胆红素产生增加的溶血。 这涉及开发和改进用于测量排出的CO的仪器和技术。这些努力与Natus Medical Inc.，San卡洛斯CA，已经导致了便携式非侵入性仪器的生产，用于床边监测潮气末呼吸CO作为所有原因的胆红素产生的指标。最近，高强度发光二极管（LED）已被研究作为一种可能的光治疗高胆红素血症。 这些功率高效、低发热的光源具有在可见光谱的蓝绿色部分中递送窄波长带的高强度光的潜力，该可见光谱的蓝绿色部分与胆红素的吸收光谱重叠。

We continue our development of carbon monoxide (CO)-monitoring technology for laboratory and bedside diagnosis of hemolysis of increased total bilirubin production from other causes. This involves developing and refining instrumentation and techniques for the measurement of excreted CO. These efforts with the cooperation of Natus Medical Inc., San Carlos CA, have resulted in the production of a portable non-invasive instrument for the bed-side monitoring of end-tidal breath CO as an index of bilirubin production for all causes. Recently, high intensity light-emitting diodes (LEDS) have been studied as a possible light for phototherapy of hyperbilirubinemia. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin.