INFANT HEME CATABOLISM AND CARBON MONOXIDE DETECTION

我们继续开发一氧化碳(CO)监测技术，用于实验室和床边诊断其他原因导致的总胆红素生成增加的溶血。这包括开发和改进测量排出的CO的仪器和技术。这些努力与加利福尼亚州圣卡洛斯的Natus医疗公司合作，已经生产出一种便携式非侵入性仪器，用于床边监测呼气末CO，作为各种原因的胆红素产生的指标。近年来，高强度发光二极管(LED)被认为是治疗高胆红素血症的一种可能的光源。这些高能效、低发热的光源有可能在可见光光谱的蓝绿色部分发射窄波带的高强度光，该部分与胆红素的吸收光谱重叠。

We continue our development of carbon monoxide (CO)-monitoring technology for laboratory and bedside diagnosis of hemolysis of increased total bilirubin production from other causes. This involves developing and refining instrumentation and techniques for the measurement of excreted CO. These efforts with the cooperation of Natus Medical Inc., San Carlos CA, have resulted in the production of a portable non-invasive instrument for the bed-side monitoring of end-tidal breath CO as an index of bilirubin production for all causes. Recently, high intensity light-emitting diodes (LEDS) have been studied as a possible light for phototherapy of hyperbilirubinemia. These power-efficient, low heat-producing light sources have the potential to deliver high intensity light of narrow wavelength band in the blue-green portion of the visible light spectrum, which overlaps the absorption spectrum of bilirubin.