BRAIN METABOLISM AND FUNCTION IN HYPOXIA
缺氧时的脑代谢和功能
基本信息
- 批准号:6410494
- 负责人:
- 金额:$ 18.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-12-01 至 2001-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Maintenance of the phosphorylation state of the brain, which is essential
for cellular viability and normal brain function, requires an unimpeded
supply of glucose and oxygen. Under conditions of oxygen insufficiency,
changes in certain modulators (such as ATP, G-6-P, G-1,6-DP) may enhance
the rate of glucose utilization by their action on key enzyme in the
respective metabolic pathways. In addition, with development in early
life, the proportion of glucose oxidized to carbon dioxide and water in
the citric acid cycle to that metabolized to pyruvate and lactate in the
glycolytic and hexosemonophosphate pathways changes dramatically. The
primary objective of this project is to investigate how hypoxia impacts
upon the mechanisms which regulate brain glucose metabolism during
development. This project will center on the enzymatic control of the
respective fluxes through hexokinase, glucose-6-phosphate dehydrogenase,
and alpha-ketoglutarate dehydrogenase complex in the neocortex of
immature and mature rats exposed to acute and chronic periods of hypoxia.
These enzymes are situated at important flux-controlling points in their
respective metabolic pathways, namely, the glycolytic pathway
(hexokinase), the hexosemonophosphate pathway (glucose-6-phosphate
dehydrogenase), and the citric acid cycle (alpha-ketoglutarate
dehydrogenase complex). Our general hypothesis is that differences in
the regulation of specific metabolic pathways contributing to the
maintenance of the phosphorylation state are the result of changes in key
enzymatic activities or their modulators. Using in-vivo and in-vitro NMR
Spectroscopy, Magnetic Resonance Imaging and enzymatic assays in=vitro,
we will examine not only the maturation of glucose flux, the mechanisms
involved and the effect of hypoxia on these but also the importance and
the role that such fluxes play in nerve cell function and survival
potential in the immature and mature subject. The uniqueness of this
project derives from 1) the approach of combining in vivo and in-vitro
techniques, 2) the track record of the investigators in addressing
questions using NMR, and 3) the fact that this project complements
others within the Program regarding issues on intermediary metabolism and
mechanisms of survival during hypoxic stress.
维持大脑的磷酸化状态,这是必不可少的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KEVIN L BEHAR其他文献
KEVIN L BEHAR的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KEVIN L BEHAR', 18)}}的其他基金
Ex Vivo Assay for In Situ Brain-Wide Mapping of Glutamate/GABA Metabolism
谷氨酸/GABA 代谢原位全脑图谱的离体测定
- 批准号:
8660339 - 财政年份:2011
- 资助金额:
$ 18.52万 - 项目类别:
Ex Vivo Assay for In Situ Brain-Wide Mapping of Glutamate/GABA Metabolism
谷氨酸/GABA 代谢原位全脑图谱的离体测定
- 批准号:
8306727 - 财政年份:2011
- 资助金额:
$ 18.52万 - 项目类别:
Ex Vivo Assay for In Situ Brain-Wide Mapping of Glutamate/GABA Metabolism
谷氨酸/GABA 代谢原位全脑图谱的离体测定
- 批准号:
8461221 - 财政年份:2011
- 资助金额:
$ 18.52万 - 项目类别:
Ex Vivo Assay for In Situ Brain-Wide Mapping of Glutamate/GABA Metabolism
谷氨酸/GABA 代谢原位全脑图谱的离体测定
- 批准号:
8192458 - 财政年份:2011
- 资助金额:
$ 18.52万 - 项目类别:
NMR Studies of Brain Energetics & Hypoglycemia In Vivo
脑能量学的核磁共振研究
- 批准号:
7920638 - 财政年份:2009
- 资助金额:
$ 18.52万 - 项目类别:
BRAIN METABOLISM & FUNCTION IN HYPOXIA: DVMT, INJURY & ADAPTION MECHANISMS
大脑新陈代谢
- 批准号:
6254300 - 财政年份:1997
- 资助金额:
$ 18.52万 - 项目类别:
相似海外基金
Brain metabolism across the lifespan using multi-parametric MRS
使用多参数 MRS 分析整个生命周期的脑代谢
- 批准号:
10738647 - 财政年份:2023
- 资助金额:
$ 18.52万 - 项目类别:
Quantifying the Brain Metabolism Underlying Task-Based BOLD Imaging
量化基于任务的 BOLD 成像背后的大脑代谢
- 批准号:
10432379 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Novel 10.5 T deuterium-based MRS/I method to measure brain metabolism
测量脑代谢的新型 10.5 T 氘 MRS/I 方法
- 批准号:
10442075 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Neuroimaging study of the effects of phospholipase A2 (PLA2) inhibition on brain metabolism and neuroinflammation in a rat model of Alzheimer’s Disease.
神经影像学研究磷脂酶 A2 (PLA2) 抑制对阿尔茨海默病大鼠模型脑代谢和神经炎症的影响。
- 批准号:
486273 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Studentship Programs
Dynamics of Cellular Brain Metabolism Using Mass Spectrometry Imaging
使用质谱成像研究细胞脑代谢动力学
- 批准号:
10556434 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
In vivo MRI Measures of Brain Metabolism in Traumatic Brain Injury
创伤性脑损伤中脑代谢的体内 MRI 测量
- 批准号:
10444479 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Quantifying the Brain Metabolism Underlying Task-Based BOLD Imaging
量化基于任务的 BOLD 成像背后的大脑代谢
- 批准号:
10816746 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Dynamics of cellular brain metabolism using mass spectrometry imaging
使用质谱成像研究细胞脑代谢动力学
- 批准号:
10418219 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial
PhytoSERM 预防更年期相关脑代谢和认知能力下降的功效:双盲、随机、安慰剂对照 2 期临床试验
- 批准号:
10560591 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别:
Brain metabolism during task-evoked and spontaneous activity in aging and Alzheimer's disease
衰老和阿尔茨海默病中任务诱发和自发活动期间的大脑代谢
- 批准号:
10585419 - 财政年份:2022
- 资助金额:
$ 18.52万 - 项目类别: