Visual Attention Selection Negativity in Schizophrenia

精神分裂症的视觉注意选择消极性

• 批准号: 6557631
• 负责人: Antigona Martinez
• 金额: $ 8.45万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6557631
• 关键词: attention; brain electrical activity; brain imaging /visualization /scanning; clinical research; cognition disorders; electrophysiology; evoked potentials; functional magnetic resonance imaging; human subject; neural information processing; neurophysiology; patient oriented research; psychological concentration; schizophrenia; sensory discrimination; visual feedback; visual pathways

Schizophrenia is a devastating mental illness that includes severe disturbances in patients' ability to allocate and sustain attention on behaviorally relevant information. Although attentional dysfunction is one of the root causes of the cognitive deficits and general impairments in information processing that are characteristic of persons afflicted with schizophrenia, the underlying neurophysiological substrates of these deficits are poorly understood. Numerous studies have attempted to characterize pathophysiology in the neuroanatomical visual pathways of schizophrenia patients. The findings from many of these converge to suggest that dysfunctional processing of the magnocellular system may give rise to subsequent high-order cognitive deficits in working memory, executive functioning and attention. The overall goal of this project is to utilize electrophysiological and functional neuroimaging measures of neural activity in order to delineate the neuroanatomical and temporal bases of selective visual attention deficits in schizophrenia patients and, in particular, how these deficits relate to sensory processing within the magnocellular and parvocellular visual pathways.

精神分裂症是一种毁灭性的精神疾病，患者分配和维持对行为相关信息的注意力的能力受到严重干扰。尽管注意力功能障碍是精神分裂症患者特征性的认知缺陷和信息处理一般障碍的根本原因之一，但这些缺陷的潜在神经生理学基础却知之甚少。许多研究试图描述精神分裂症患者神经解剖视觉通路的病理生理学特征。其中许多研究结果集中表明，大细胞系统的功能失调可能会导致随后的工作记忆、执行功能和注意力方面的高阶认知缺陷。该项目的总体目标是利用神经活动的电生理学和功能性神经影像学测量来描绘精神分裂症患者选择性视觉注意缺陷的神经解剖学和时间基础，特别是这些缺陷如何与大细胞和小细胞视觉通路内的感觉处理相关。