HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AND LYMPHOID IRRADIATION IN HIV DISEASE

HIV 疾病中的高效抗逆转录病毒治疗和淋巴照射

• 批准号: 6305609
• 负责人: JOSEPH M MCCUNE
• 金额: $ 0.06万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305609
• 关键词: AIDS; AIDS therapy; antiviral agents; clinical research; clinical trial phase I; human subject; human therapy evaluation; lymphatic tissue; radiation therapy; thymus; virus replication

This study is a second in a series designed to evaluate the role of the thymus in HIV disease and utilizes highly active anti-retroviral therapy to suppress viral replication and spread within intrathymic compartments. The investigator will then initiate studies to test the possibility that total lymphoid irradiation (TLI) may serve to reduce the total body viral load and facilitate thymic repopulation of the periphery. By shielding the thymus from the effects of such radiation and by administering highly active anti-retroviral therapy concomitantly, infected T and myloid cells in the peripheral lymphoid system may be eliminated, viral spread from surviving infected cells may be suppressed, and the peripheral system may be repopulated with naive T-cells emigrating from the thymus. This study is primarily designed to test the safety and feasibility of such approach as well as to provide extensive evaluation of virologic, immunologic, and clinical parameters.

这项研究是一系列旨在评估胸腺在HIV疾病中的作用的研究中的第二项，该研究利用高活性抗逆转录病毒疗法来抑制病毒在胸腺腔内的复制和传播。然后，研究者将开始研究，以测试全淋巴照射（TLI）可能有助于降低全身病毒载量和促进胸腺外周细胞再生的可能性。通过保护胸腺免受这种辐射的影响，并同时给予高活性的抗逆转录病毒治疗，可以消除外周淋巴系统中受感染的T细胞和髓样细胞，抑制来自存活的感染细胞的病毒传播，并且外周系统可以由从胸腺迁移的幼稚T细胞重新填充。本研究的主要目的是测试这种方法的安全性和可行性，并提供广泛的病毒学、免疫学和临床参数评估。