SARCOPENIA: TESTOSTERONE DOSE RESPONSE IN OLDER MEN

肌肉减少症，即老年男性肌肉量的减少，已经成为一个主要的公共卫生问题。睾酮缺乏被认为是老年人瘦体重减少的一个原因。男人。然而，大多数老年男性的睾丸激素水平在正常范围内，尽管老年男性的平均睾丸激素水平低于年轻男性。因此，据推测，老年男性可能对雄激素的合成代谢作用不那么敏感。本研究的目的是比较年轻和老年男性的睾酮剂量-反应曲线。另一个目的是检查各种雄激素依赖性生理过程的睾酮剂量依赖性，如蛋白质合成、胰岛素敏感性、脂质、肌肉质量和性功能。这些数据将有助于选择替代睾酮的最佳剂量。另一个目的是比较年轻男性和老年男性的睾酮剂量反应曲线，以确定老年男性是否对睾酮的合成代谢作用相对不敏感。

Sarcopenia, the loss of muscle mass in older men, has emerged as a major public health problem. Testosterone deficiency has been proposed as one cause for the loss of lean body mass in older. men. However, most older men have testosterone levels that are in the broad normal range, albeit the average testosterone levels in older men are lower than those in younger men. Therefore, it has been speculated that older men might be less sensitive to the anabolic effects of androgens. The purpose of this study is to compare the testosterone dose-response curves in young and older men. Another objective is to examine the testosterone dose-dependency of various androgen-dependent physiologic processes such as protein synthesis, insulin sensitivity, lipids, muscle mass, and sexual function. These data would help select the optimum dose of testosterone for replacement. An additional objective is to compare the testosterone dose-response curves in young and older men in order to determine if older men are relatively insensitive to the anabolic effects of testosterone.