INFLUENCE OF ETHNICITY ON BRAIN LITHIUM--LITHIUM MRS

种族对脑锂的影响--LITHIUM MRS

• 批准号: 6306682
• 负责人: KEH M LIN
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6306682
• 关键词: bioimaging /biomedical imaging; brain metabolism; clinical research; human subject; lithium; magnetic resonance imaging; mental disorder chemotherapy; neuropharmacology; pharmacokinetics; racial /ethnic difference

To measure lithium concentrations in brain and in blood in patients already taking lithium and in normal controls given a single test-dose of the drug. Brain concentration of lithium will be measured by a special MRI procedure call- ed MR spectroscopy. Three studies are proposed: patient study with single assessment; normal volunteer with repeated measures and normal volunteer with single assessment.

测量已经服用锂的患者和给予单次试验剂量药物的正常对照组的脑和血液中的锂浓度。将通过称为艾德MR光谱的特殊MRI程序测量锂的脑浓度。拟开展三项研究：患者研究，单次评估;正常志愿者，重复测量;正常志愿者，单次评估。