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MECHANISM OF ETHNIC DIFFERENCES IN PSYCHOTROPHIC RESPONSES

MECHANISM OF ETHNIC DIFFERENCES IN PSYCHOTROPHIC RESPONSES
精神营养反应的种族差异机制
批准号：
6306634
负责人：
KEH M LIN
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6306634
关键词：
African American Asians Hispanic Americans clinical research drug metabolism drug screening /evaluation human subject pharmacokinetics psychopharmacology psychotropic drugs racial /ethnic difference

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中文摘要
翻译
比较不同种族人群对精神药物的反应，并探讨其反应差异的潜在原因。在确定响应的假设因素是：药物代谢肝酶系统的遗传差异，蛋白质结合，和饮食的影响。通过广泛的体格检查和实验室检查评估来自非洲裔美国人、亚洲人、高加索人和西班牙裔背景的受试者。研究将由两部分组成：药物遗传学&蛋白质结合和饮食影响。
英文摘要
To compare the response and explore potential reasons for differences in response to psychotropic medication in different ethnic groups. The factors hypothesized in determining response are: inherited differences in drug metabolizing liver enzyme systems, protein binding, and dietary influences. To evaluate subjects from African-American, Asian, Caucasian and Hispanic backgrounds with extensive physical and laboratory examinatins. The investigatin will be composed of two parts: pharmacogenetics & protein binding and dietary influences.
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会议论文
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Ethnic Variations in Antidepressant Response
INFLUENCE OF ETHNICITY ON BRAIN LITHIUM--LITHIUM MRS
DETERMINANTS OF CYTOCHROME P450 ACTIVITY IN HUMANS
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