Outcomes of Education and Counseling for BRCA1/2 Testing

本研究的目的是：1）确定家庭特征和个性特征以及对BRCA 1检测的个人决定有显著影响的信仰，例如宗教和精神信仰以及先前的癌症直接经历; 2）描述阴性与阳性BRCA 1检测结果对家庭关系和心理状态的影响; 3）根据个人人格特征预测对有关风险状况的特定咨询的反应; 4）预测谁最有可能经历对亲密关系的负面影响; 5）评估对检测的期望以及这些期望如何影响对风险的感知和对风险通知的反应; 6）评估风险通知对监测和预防活动频率的影响;和7）比较客户驱动的预测试会话与顾问驱动的解决问题的方法。迄今为止，已与来自11个大家庭的556人进行了联系。256人（46%）参加了这项研究，220人（86%）选择接受基因检测。173人已收到他们的测试结果。预测测试的决定，包括社会人口统计学和人格特质进行了分析。年龄、婚姻状况、家庭凝聚力和乐观情绪是决定接受测试的预测因素。这些基线结果目前正在提交供出版。- 乳腺癌-人类受试者

The objectives of the study are; 1) to identify family characteristics and personality traits and beliefs that significantly effect individual decisions regarding BRCA1 testing such as, religious and spiritual beliefs and previous direct experience with cancer; 2) to characterize the impact of negative vs. positive BRCA1 testresults on family relationships and psychological status; 3) to predict responses to specific counseling regarding risk status based on individual personality profiles; 4) to predict who is at greatest risk for experiencing negative effects on close relationships; 5) to assess expectations regarding testing and how these influence perceptions of risks and responses to risk notification; 6) to evaluate the impact of risk notification on the frequency of surveillance and prevention activities; and 7) to compare a client-driven pre-test session to a counselor-driven, problem-solving approach. To date, 556 individuals from eleven extended families have been contacted. Two hundred fifty six (46%) have participated in the study and 220 (86% of those counseled) have chosen to undergo genetic testing. One hundred seventy three individuals have received their test results. Predictors of testing decisions including, sociodemographics and personality traits have been analyzed. Age, marital status, family cohesion and optimism are predictive of the decision to be tested. These baseline results currently are being submitted for publication. - Breast Cancer - Human Subjects