Outcomes of Education and Counseling for BRCA1/2 Testing

遗传性乳腺癌和卵巢癌研究家庭的成员有机会接受教育和咨询，以决定是否接受BRCA1/2测试。此前，国家癌症研究所通过遗传流行病学研究确定了携带基因突变的家庭。本次研究共招募了来自16个大家庭的262名参与者。在基线时，参与者被问及他们对自己癌症风险的理解、他们的筛查行为、他们对癌症的担忧、应对策略、家庭环境、自尊、抑郁状态和乐观/悲观。其中许多参数在通知测试结果后6个月和12个月再次进行评估，或对未测试的参数在平行的时间点进行评估。基线数据的结果发表在《美国医学遗传学杂志》上。研究表明，年龄、悲观和家庭凝聚力对测验决策有预测作用。目前正在对后续数据进行分析。

Members of Hereditary Breast and Ovarian Cancer Research Families were offered the opportunity to undergo education and counseling about a decision whether or not to undergo BRCA1/2 testing. Families were previously identified through genetic epidemiology studies at the National Cancer Institute to carry genetic mutations. Total recruitment into the study was 262 participants from sixteen extended families. At baseline participants were asked their understanding of their own cancer risk, their screening behaviors, their cancer worries, coping strategies, family environment, self-esteem, depression status and optimism/pessimism using standardized measures. Many of these parameters were assessed again at 6 and 12 months following notification of test results, or for those not tested, at parallel time points. Results of the baseline data were published in the American Journal of Medical Genetics. The manuscript indicates that age, pessimism and family cohesion were predictive of test decision-making. Analysis of the follow-up data is currently underway.