CARDIOVASCULAR FLOW DYNAMICS--IN VIVO IMAGING STUDIES

心血管血流动力学——体内成像研究

• 批准号: 6432696
• 负责人: M JONES
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432696
• 关键词: cardiovascular disorder diagnosis; diagnosis quality /standard; echocardiography; heart circulation; heart disorder diagnosis; heart function; hemodynamics; intracardiac volume; mitral valve stenosis; noninvasive diagnosis; sheep; ultrasound blood flow measurement

This project emphasizes studies using newly emerging robust non invasive ultrasonic imaging technologies for quantifying structural and functional cardiovascular pathology. Using hydrodynamic principles, temporal and spatial aspects of cardiac structural abnormalities and pathophysiologic flow events are described and their quantification validated. In the clinical management of cardiac dysfunction, quantitativelyaccurate assessment is of major importance for diagnosis, prognosis and therapy. Non invasive assessment is, in addition, economically desirable. To these ends, the current year's efforts have extended previous years' studies to include: 1) In ex vivo animal studies, a strong correlation was validated between actual left ventricular volumes and those calculated with real-time, three-dimensional echocardiography. 2) In vivo, apically rotated 6 plane measurement methods with real-time, three-dimensional echocardiography correlated well with reference standards for calculating left ventricular volumes when compared with electromagnetic flow probe methods and magnetic resonance imaging. 3) Real-time, three-dimensional echocardiography was also validated for quantifying left ventricular volumes in the presence of left ventricular asymmetry, i.e. in the presence of left ventricular aneurysms. 4) Using real-time, three-dimensional color Doppler with its unique c-plane, which is perpendicular to flow, the cross-sectional spatial velocity distributions in the left ventricular outflow tract were imaged. 5) Peak flow rates were obtained by spatially integrating the velocity data from the cross-sectional color images of the left ventricular outflow tract. Thus, estimations of peak flow rates were possible without any assumptions about flow velocity geometric distribution. 6) By applying a temporal averaging factor to correct for underestimation, there was an excellent agreement between reference flow rate by electromagnetic flow meter and real-time, three-dimensional color Doppler echocardiography. These studies have been published or are in press. On-going studies using three-dimensional structural imaging and three-dimensional Doppler flow imaging use animal models of chronic aortic and mitral regurgitation.

该项目强调使用新兴的强大的非侵入性超声成像技术来量化结构和功能性心血管病理学的研究。 使用流体动力学原理，时间和空间方面的心脏结构异常和病理生理流事件的描述和量化验证。在心功能不全的临床治疗中，准确的定量评估对诊断、预后和治疗具有重要意义。 此外，非侵入性评估在经济上是可取的。 为此，本年度的努力扩展了往年的研究，包括：1）在离体动物研究中，验证了实际左心室容积与实时三维超声心动图计算的左心室容积之间的强相关性。 2)在体内，与电磁流量探头方法和磁共振成像相比，实时三维超声心动图心尖旋转6平面测量方法与计算左心室容积的参考标准相关性良好。 3)还验证了实时三维超声心动图在存在左心室不对称（即存在左心室动脉瘤）的情况下量化左心室容积。 4)使用实时三维彩色多普勒，其独特的c-平面，这是垂直于流动，在左心室流出道的横截面空间速度分布成像。5)通过对左心室流出道的横截面彩色图像的速度数据进行空间积分来获得峰值流速。 因此，峰值流速的估计是可能的，而无需对流速几何分布进行任何假设。 6)通过应用时间平均因子来校正低估，电磁流量计和实时三维彩色多普勒超声心动图的参考流速之间有很好的一致性。 这些研究报告已经出版或正在印刷中。 使用三维结构成像和三维多普勒血流成像的正在进行的研究使用慢性主动脉瓣和二尖瓣返流的动物模型。