EVALUATIONS OF PROSTHETIC CARDIAC VALVES--IN VIVO STUDIES

人工心脏瓣膜的评估——体内研究

• 批准号: 3858062
• 负责人: M JONES
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3858062
• 关键词: biomaterial evaluation; disease /disorder model; echocardiography; heart circulation; heart disorder diagnosis; heart function; heart valve disorder; heart valve transplantation; hemodynamics; histopathology; homologous transplantation; juvenile animal; model design /development; noninvasive diagnosis; pathologic process; prosthetic heart valve; sheep; ultrasound blood flow measurement

SUMMARY: The studies of this project are those of the ongoing development and application of an in vivo, in situ animal model system using juvenile sheep for evaluating cardiac valves and cardiovascular flow dynamics. The studies use multiple disciplines of investigative techniques: surgery, -physiology, morphology and pathology, biomechanics, and the physical and chemical sciences. Previous years' studies have concentrated upon conventional hydraulic/hemodynamic evaluations of normal cardiac valves and prosthetic cardiac valvular substitutes, and upon morphologic and physical characterization the calcific degeneration of bioprosthetic valves. Efforts during the current year have emphasized studies of intracardiac flow dynamics for quantifying stenotic and regurgitant lesions. These studies demonstrate: 1) that observations of convergent flow using principles of momentum continuity preservation may be used to quantitate intracardiac flow volumes for both stenotic and regurgitant lesions; and 2) that clarification of both spatial (geometric) and temporal (pulsatility) characteristics are important in applying fundamental physical theories of fluid mechanics to the complexities of cardiac valvular flow dynamics.

摘要：本项目的研究是正在进行的开发 以及使用青少年的体内原位动物模型系统的应用 用于评估心脏瓣膜和心血管血流动力学的绵羊。 这些研究使用了多学科的调查技术： 手术，-生理学，形态学和病理学，生物力学， 物理和化学科学。 前几年的研究表明， 集中于常规的液压/血液动力学评价， 正常心脏瓣膜和人工心脏瓣膜替代物，以及 根据形态和物理特征， 人工生物瓣膜 本年度的工作强调， 心内血流动力学研究，用于定量狭窄和 易变性病变。 这些研究表明：（1）观察 使用动量连续性保持原理的会聚流可以 用于定量狭窄和狭窄的心内流量， （2）明确两个空间位置; （几何）和时间（脉动）特征在 应用流体力学的基本物理理论， 心脏瓣膜血流动力学的复杂性。