EVALUATIONS OF PROSTHETIC CARDIAC VALVES--IN VIVO STUDIES

人工心脏瓣膜的评估——体内研究

• 批准号: 3878976
• 负责人: M JONES
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3878976
• 关键词: biomaterial evaluation; disease /disorder model; echocardiography; heart circulation; heart disorder diagnosis; heart function; heart valve disorder; heart valve transplantation; hemodynamics; histopathology; homologous transplantation; juvenile animal; mitral valve; model design /development; nonblood rheology; noninvasive diagnosis; pathologic process; prosthetic heart valve; sheep; ultrasound blood flow measurement

The studies of this project are those of the ongoing use of juvenile sheep for evaluating cardiac valve pathology and pathophysiology. Previous years' studies have concentrated upon conventional hydraulic/hemodynamic evaluations of native and prosthetic cardiac valves, and upon the morphologic and physical characterization of calcific degeneration of bioprosthetic valves. Efforts during the current year explored the following areas: (1) studies of homograft mitral valve substitutes; and (2) studies of Doppler determined intracardiac flow dynamics. The first studies have demonstrated the feasibility of homograft mitral valve replacement, providing a unique mode for investigating mechanisms of bioprosthetic valve leaflet degeneration and mineralization. The current studies have added credence to the hypothesis that preimplantation glutaraldehyde treatment facilitates mineralization. Two-dimensional, color-encoded Doppler evaluations of intracardiac flow dynamics using fundamental physical theories of jet flux and momentum continuity preservation have provided quantitative volumetric information regarding valvular regurgitation.

该项目的研究是那些正在进行的使用幼羊 用于评价心脏瓣膜病理学和病理生理学。 先前 多年的研究集中在传统的液压/血液动力学 评价天然和人工心脏瓣膜， 钙化变性的形态和物理特征 生物瓣膜 本年度的努力探讨了 以下领域：（1）同种二尖瓣替代物的研究; (2)多普勒测定心内血流动力学的研究。 第一 研究已经证明了同种二尖瓣移植的可行性 替代，提供了一个独特的模式，调查机制， 生物瓣膜瓣叶退化和矿化。 当前 研究进一步证实了胚胎植入前 戊二醛处理促进矿化。 二维的， 彩色编码多普勒评价心内血流动力学， 射流通量和动量连续性的基本物理理论 保存提供了定量的体积信息， 瓣膜返流