Development of Etched Modified Capillaries

描述（由申请人提供）：这份STTR提案描述了圣何塞州立大学和Microsolv技术公司之间的合作项目，用于开发和销售用于毛细管电泳和相关技术的蚀刻改性毛细管。开发的重点包括用二氟化氢铵蚀刻熔融二氧化硅毛细管的格式，然后通过将有机部分附着在毛细管壁上或通过物理涂覆聚合物或表面活性剂进行化学改性。键合过程采用硅烷化/氢化方法，以稳定的硅碳键连接有机部分。这些材料的可能应用包括制药、多肽和蛋白质。通过Microsolv与一些工业实验室之间的合作安排，将测试蚀刻改性毛细血管在实际应用中的实用性。主要的开发工作将在圣何塞州立大学继续进行，以改进现有的形式，并为更广泛的应用或根据工业实验室测试的反馈制造新材料。Microsolv公司将进行一项营销计划，以分发产品，供在目标应用领域工作的公司使用。

DESCRIPTION (provided by applicant): This STTR proposal describes a collaborative project between San Jose State University and Microsolv Technology Corporation for the development and marketing of etched modified capillaries for use in capillary electrophoresis and related techniques. The focus of the development involves a format for etching fused silica capillaries with ammonium hydrogen difluoride followed by chemical modification through attachment of an organic moiety to the capillary wall or by physically coating a polymer or surfactant. The bonding process utilizes the silanization/hydrosilation method in order to attach the organic moiety with a stable silicon-carbon linkage. The likely applications of these materials involve pharmaceuticals, peptides and proteins. Through cooperative arrangements between Microsolv and a number of industrial labs, the etched modified capillaries will be tested for their usefulness in practical applications. The major development work will continue at San Jose State in order to improve on the formats currently available as well as to fabricate new materials for a broader range of applications or in response to feedback from the industrial lab tests. Microsolv Corporation will undertake a marketing plan to distribute the products for use by companies working in the targeted application areas.