METAL-PROTEINS STUDIES BY FLUORESCENCE SPECTROSCOPY AND HALIDE ION NMR

通过荧光光谱和卤化物离子核磁共振研究金属蛋白质

基本信息

  • 批准号:
    3915932
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

The study of metal ions in biochemical systems encompasses two significant aspects of enzyme reactions. First, the metalloenzymes and metal activated enzymes that require the presence of the metal in order for the enzyme to carry out its function and second, the enzyme systems which are disrupted or inhibited by the presence of certain metal ions (primarily the heavy metals). This study proposes to use the native fluorescence of the amino in enzymes to gather information about these two aspects of enzyme reactions. This means that no external probe will have to be added which may perturb the enzyme or disrupt the effect of the metal. The other method used in this study is halide ion NMR. This technique can be used to detect binding of the metal ion and to determine the accessibility to and local motion at the binding site. If successful, the techniques developed in this study will help to design new drugs for the treatment of heavy metal poisoning and would provide fundamental information about the role of the metal ion in metalloenzymes and metal activated biochemical systems.
金属离子在生化系统中的研究包括两个方面

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

JOSEPH J PESEK其他文献

JOSEPH J PESEK的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('JOSEPH J PESEK', 18)}}的其他基金

Open Tubular Capillary Electrochromatography/Mass Spectroscopy
开管毛细管电色谱/质谱
  • 批准号:
    7193346
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
Development of Etched Modified Capillaries
蚀刻改性毛细管的开发
  • 批准号:
    6550299
  • 财政年份:
    2002
  • 资助金额:
    --
  • 项目类别:
The Development of Capillary Electrochromatography
毛细管电色谱的发展
  • 批准号:
    6357609
  • 财政年份:
    2001
  • 资助金额:
    --
  • 项目类别:
NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY
用于色谱的新型手性固定相
  • 批准号:
    2193736
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:
NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY
用于色谱的新型手性固定相
  • 批准号:
    2430501
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:
SEPARATION OF BIOMOLECULES BY ELECTROMATOGRAPHY
通过电子成像技术分离生物分子
  • 批准号:
    2187015
  • 财政年份:
    1993
  • 资助金额:
    --
  • 项目类别:
METAL-PROTEINS STUDIES BY FLUORESCENCE SPECTROSCOPY AND HALIDE ION NMR
通过荧光光谱和卤化物离子核磁共振研究金属蛋白质
  • 批准号:
    3937063
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
METAL-PROTEINS STUDIES BY FLUORESCENCE SPECTROSCOPY AND HALIDE ION NMR
通过荧光光谱和卤化物离子核磁共振研究金属蛋白质
  • 批准号:
    3877541
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
METAL-PROTEINS STUDIES BY FLUORESCENCE SPECTROSCOPY AND HALIDE ION NMR
通过荧光光谱和卤化物离子核磁共振研究金属蛋白质
  • 批准号:
    3959746
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Development of physiological index on the stress tolerance and the analytical method of distribution of riparian trees
河岸树木抗逆生理指标的建立及分布分析方法
  • 批准号:
    23K04040
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of an analytical method for relationships between diseases and attributes using health screening records
使用健康检查记录开发疾病与属性之间关系的分析方法
  • 批准号:
    23KJ0256
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Task C2: Analytical Method, Process Development and Manufacturing for Therapeutics
任务 C2:治疗药物的分析方法、工艺开发和制造
  • 批准号:
    10918695
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Development of sensitive intracellular molecular analytical method by single-cell organelle injection and derivatization
通过单细胞细胞器注射和衍生化开发灵敏的细胞内分子分析方法
  • 批准号:
    22K06551
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
History of chemical exposure from fetal to infancy: development of deciduous tooth analytical method for exposome
从胎儿到婴儿期的化学暴露史:乳牙暴露组分析方法的发展
  • 批准号:
    22K19853
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Developement of analytical method for new designer drugs by using accurate mass data base
利用精确质量数据库开发新设计药物的分析方法
  • 批准号:
    22K21157
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
Development and standardization of 14C analytical method by one-step graphitization of methane
甲烷一步石墨化14C分析方法的开发和标准化
  • 批准号:
    22K03801
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development and application of a comprehensive analytical method for oxidized lipids
氧化脂质综合分析方法的开发及应用
  • 批准号:
    22J10781
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
ANALYTICAL METHOD DEVELOPMENT, VALIDATION AND STABILITY STUDY OF ORC-13661
ORC-13661 的分析方法开发、验证和稳定性研究
  • 批准号:
    10972995
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Development of analytical method for exosome in exhaled breath condensate using a surface plasmon resonance sensor
使用表面等离子体共振传感器开发呼出气冷凝液中外泌体的分析方法
  • 批准号:
    21K18985
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了