NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY

拟议项目的重点是开发新的文具 几种不同色谱手性分离的相 方法：高效液相色谱法，超临界 流体层析(SFC)和毛细管电色谱(CEC)。这个 对映体的分离是一个日益重要的分析问题。 在药物开发、农用化学品和生物技术方面。新的方法 手性拆分在对映体的监测中都是需要的 此外，还可用于制备光学纯材料。高效液相色谱仪 既可用于分析，也可用于制备目的。而手性 目前有固定相可用，它们并不适用于所有 对映体的分离，因此新型相的发展是 需要的，尤指为了准备的目的。几种新型材料 基于已证实的合成方法，讨论了使用新化合物 在这份提案中。将对高效液相色谱进行初步测试的新阶段 随后，通过一种新的毛细管格式，进一步发展了SFC和CEC。 这项技术包括蚀刻毛细血管的内壁以 增加表面积，然后将所需的手性实体键合到 改善溶质/键合相相互作用的新表面。这个 结合新的手性材料以及新的方法 对映体的分离应该会扩大两者的能力 分析和准备目的。

The focus of the proposed project is on the development of new stationary phases for chiral separations in several different chromatographic methods: high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and capillary electrochromatography (CEC). The separation of enantiomers is an increasingly important analytical problem in drug development, agrochemicals and biotechnology. New approaches for chiral separations are needed in both the monitoring of enantiomeric purity as well as for the preparation of optically pure materials. HPLC can be used for both analytical and preparative purposes. While chiral stationary phases are currently available, they are not applicable to all enantiomeric separations so the development of new types of phases is needed, especially for preparative purposes. Some new types of materials based on proven synthetic approaches using novel compounds are discussed in this proposal. The new phases which will be initially tested for HPLC followed by further development in SFC and CEC via a new capillary format. This technique involves etching the inner walls of the capillaries to increase the surface area and than bonding the desired chiral entity to the new surface to improve solute/bonded phase interactions. The combination of new chiral materials as well as new approaches for enantiomeric separations should result in expanded capabilities for both analytical and preparative purposes.