NEW CHIRAL STATIONARY PHASES FOR CHROMATOGRAPHY

用于色谱的新型手性固定相

• 批准号: 2430501
• 负责人: JOSEPH J PESEK
• 金额: $ 4.83万
• 依托单位: SAN JOSE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2430501
• 关键词: benzoates; biomedical equipment development; chemical synthesis; chromatography; silanes; stereoisomer

The focus of the proposed project is on the development of new stationary phases for chiral separations in several different chromatographic methods: high performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC) and capillary electrochromatography (CEC). The separation of enantiomers is an increasingly important analytical problem in drug development, agrochemicals and biotechnology. New approaches for chiral separations are needed in both the monitoring of enantiomeric purity as well as for the preparation of optically pure materials. HPLC can be used for both analytical and preparative purposes. While chiral stationary phases are currently available, they are not applicable to all enantiomeric separations so the development of new types of phases is needed, especially for preparative purposes. Some new types of materials based on proven synthetic approaches using novel compounds are discussed in this proposal. The new phases which will be initially tested for HPLC followed by further development in SFC and CEC via a new capillary format. This technique involves etching the inner walls of the capillaries to increase the surface area and than bonding the desired chiral entity to the new surface to improve solute/bonded phase interactions. The combination of new chiral materials as well as new approaches for enantiomeric separations should result in expanded capabilities for both analytical and preparative purposes.

拟议项目的重点是开发新的文具 在几种不同的色谱分离中用于手性分离的相 方法：高效液相色谱法（HPLC），超临界 流体色谱（SFC）和毛细管电色谱（CEC）。的 对映体的分离是一个日益重要的分析问题 药物开发、农用化学品和生物技术。的新途径 在对映异构体的监测中， 纯度以及用于制备光学纯材料。HPLC 可用于分析和制备目的。虽然手性 固定相是目前可用的，它们不适用于所有 对映体分离，因此开发新类型的相是 特别是为了准备的目的。一些新型材料 基于已证实的合成方法，使用新的化合物进行了讨论 在这个提议中。最初将进行HPLC检测的新相 随后通过新的毛细管形式在SFC和CEC中进一步发展。 该技术涉及蚀刻毛细管的内壁， 增加表面积，然后将所需的手性实体键合到 新的表面，以改善溶质/键合相的相互作用。的 新的手性材料的组合以及新的方法， 对映体分离应导致扩大的能力， 分析和准备的目的。