Destruction of Air-Borne Pathogenic Bacteria

破坏空气中的致病菌

• 批准号: 6555351
• 负责人: JAMES R KITTRELL
• 金额: $ 10万
• 依托单位: KSE, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2003-03-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6555351
• 关键词: Bacillus anthracis; air filtration; air sampling /monitoring; air treatment; antibacterial agents; bacterial cytopathogenic effect; biomedical equipment development; bioterrorism /chemical warfare; catalyst; photochemistry; technology /technique development

DESCRIPTION (provided by applicant): The objective of this research project is to establish the technical and economic feasibility of a novel photocatalytic technology to inactivate air-borne Bacillus anthracis (anthrax), using representative surrogate bacterial spores, B. cereus. The technology is to be incorporated into circulating air ducts of buildings, providing protection against introduction of anthrax bacteria into central air systems by a terrorist act. There is also a need for a technology which can inactivate a broad range of such pathogens, since bioengineering could lead to modified anthrax spores. Such a broad acting technology could also find immediate applicability in curing "sick building" syndrome, by destroying other microorganisms and organic vapors in indoor air. KSE, Inc. has already developed a new class of photocatalysts, orders of magnitude more active for organic compound oxidation than the traditional titania. This new class of photocatalysts will be adapted for use in anthrax spore destruction, in cooperation with the University of Massachusetts, Department of Microbiology. The program will utilize photocatalyst composition studies to tailor a superior photocatalyst for this application, reactor studies of the bactericidal efficacy of the new photocatalysts, and a competitive cost analysis of the technology relative to other alternatives for maintenance of indoor air quality. The commercial applications will provide an air purification technology with broad bactericidal activity, particularly useful for anthrax spores, bioengineered anthrax, and other pathogens, as well as common microorganisms contributing to a "sick building." It will thus provide a central defense strategy against the threat of introduction of lethal anthrax spores into central air systems, while also providing immediate commercial benefit through improvements of indoor air quality of commercial buildings by removing organic compounds and common microorganisms.

描述（由申请人提供）：本研究项目的目的是使用代表性的替代细菌孢子B，确定一种新型光催化技术杀灭空气传播的炭疽芽孢杆菌（炭疽）的技术和经济可行性。蜡状。该技术将被纳入建筑物的循环空气管道，防止恐怖主义行为将炭疽细菌引入中央空气系统。还需要一种技术，可以消灭各种各样的这种病原体，因为生物工程可以产生改良的炭疽孢子。这种广泛作用的技术也可以通过破坏室内空气中的其他微生物和有机蒸汽来立即适用于治疗“病态建筑”综合症。 KSE公司已经开发出了一类新型的光催化剂，其对有机化合物氧化的活性比传统的二氧化钛高几个数量级。这类新的光催化剂将与马萨诸塞州大学微生物学系合作，用于炭疽孢子的破坏。该计划将利用光催化剂成分的研究，为这种应用定制一种上级光催化剂，对新型光催化剂的杀菌功效进行反应器研究，并对该技术相对于其他替代品的竞争力进行成本分析，以维持室内空气质量。 商业应用将提供一种具有广泛杀菌活性的空气净化技术，特别适用于炭疽孢子、生物工程炭疽和其他病原体，以及导致“病态建筑”的常见微生物。“因此，这将提供一个中央防御策略，防止致命的炭疽孢子进入中央空气系统的威胁，同时通过去除有机化合物和常见的微生物来改善商业建筑物的室内空气质量，从而提供直接的商业利益。”