APOPTOSIS VERSUS MALIGNANT PROGRESSION IN BREAST CANCER

乔治敦大学正在研究染色体的作用机制 乳腺癌中的不稳定性，尤其是扩增或 几个癌基因和抑癌基因的突变。他们很专注 论myc癌基因在转基因小鼠模型中的作用 他们可以通过这个系统来研究它在乳腺肿瘤发生中的作用。这个 具体目标是从FVB中获得已分类的小鼠染色体 菌株，荧光标记这些染色体以建立多色 乔治敦大学的鱼类光谱核型分析，并使用这项技术来 建立诱发的染色体不稳定的时间依赖性 C-myc癌基因在小鼠乳腺上皮细胞中的表达。

Georgetown University is studying the mechanisms of chromosomal instability in breast cancer, in particular the amplification or mutation of several oncogenes and suppresser genes. They are focused on the role of the myc oncogene in transgenic mouse models as a model system whereby they may study its role in mammary tumorigenesis. The specific aims are to obtain sorted mouse chromosomes from the FVB strain, fluorescently label these chromosomes to establish multicolor FISH spectral karyotyping at Georgetown, and to use this technique to establish the time dependent nature of chromosomal instability induced by the c-myc oncogene in mouse mammary epithelial cells.