STRUCTURAL STUDIES OF ACETATE KINASE

神经营养因子NGF（神经生长因子）、BDNF（脑源性 生长因子）和NT 3（神经营养因子-3）介导存活， 神经元通过其特异性非共价结合的分化 作为与细胞表面受体trkA、trkB和trkC的同源二聚体， 跨膜酪氨酸激酶同一家族的成员。 而 晶体结构存在的神经生长因子和细胞外结构域， 跨膜酪氨酸激酶（EGF受体），知之甚少 关于这些组之间特异性的结构基础， 分子。 这些知识是开发分子生物学所必需的。 神经系统退行性疾病的治疗方法。

The neurotrophins NGF (nerve growth factor), BDNF (brain-derived growth factor), and NT3 (neurotrophin-3) mediate the survival and differentiation of neurons via their specific noncovalent association as homodimers with cell surface receptors, trkA, trkB, and trkC, members of the same family of transmembrane tyrosine kinases. While crystal structures exist for NGF and an extracellular domain of a transmembrane tyrosine kinases (EGF receptor), little is known regarding the structural basis of specificity between these sets of molecules. Such knowledge is needed to develop a molecular therapeutic approach to degenerative diseases of the nervous system.