课题基金 / 基金详情

STRUCTURAL STUDIES OF ACETATE KINASE

STRUCTURAL STUDIES OF ACETATE KINASE
乙酸激酶的结构研究
批准号:
6437658
负责人:
DOUGLAS CHARLES REES
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-03-01 至 2002-02-28

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中文摘要
翻译
神经营养因子NGF(神经生长因子),BDNF(脑源性
英文摘要
The neurotrophins NGF (nerve growth factor), BDNF (brain-derived growth factor), and NT3 (neurotrophin-3) mediate the survival and differentiation of neurons via their specific noncovalent association as homodimers with cell surface receptors, trkA, trkB, and trkC, members of the same family of transmembrane tyrosine kinases. While crystal structures exist for NGF and an extracellular domain of a transmembrane tyrosine kinases (EGF receptor), little is known regarding the structural basis of specificity between these sets of molecules. Such knowledge is needed to develop a molecular therapeutic approach to degenerative diseases of the nervous system.
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CALTECH PRT TIME
  • 批准号:
    8362064
  • 项目类别:
  • 资助金额:
    $0.27万
  • 财政年份:
    2011
  • 负责人:
    DOUGLAS CHARLES REES
  • 依托单位:
REES 12-2 PRT
  • 批准号:
    8362338
  • 项目类别:
  • 资助金额:
    $0.03万
  • 财政年份:
    2011
  • 负责人:
    DOUGLAS CHARLES REES
  • 依托单位:
CALIFORNIA INSTITUTE OF TECHNOLOGY STRUCTURAL BIOLOGY SCIENCE
  • 批准号:
    8362337
  • 项目类别:
  • 资助金额:
    $0.8万
  • 财政年份:
    2011
  • 负责人:
    DOUGLAS CHARLES REES
  • 依托单位:
CALIFORNIA INSTITUTE OF TECHNOLOGY STRUCTURAL BIOLOGY SCIENCE
  • 批准号:
    8170342
  • 项目类别:
  • 资助金额:
    $0.54万
  • 财政年份:
    2010
  • 负责人:
    DOUGLAS CHARLES REES
  • 依托单位:
海外基金