Cyclotron for PET Isotope Production

用于 PET 同位素生产的回旋加速器

• 批准号: 6500598
• 负责人: KENNETH A. KROHN
• 金额: $ 163.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6500598
• 关键词: biomedical equipment purchase; particle accelerators; positron emission tomography; radionuclides

DESCRIPTION (provided by applicant): This proposal is for a new cyclotron to support imaging research at the University of Washington. This is an exciting time for imaging in medicine with new imaging tools being developed and used to answer important questions at the cutting edge of human biology. The UW Molecular Imaging Center is a focus for collaborative and innovative research using advanced methods for non-invasive imaging of biochemical reactions in vivo. The majority of our research that will benefit from the proposed cyclotron exploits the high spatial and temporal resolution capabilities of quantitative positron emission tomography (PET). The UW PET program is 17 yrs old and is a leader in cancer and cardiac imaging research. Until now, we have purchased time on a cyclotron in the Department of Radiation Oncology. We now require a dedicated instrument to support our expanding research projects. PET imaging is being used by almost half of our medical school departments, including both basic science and clinical projects. This application describes the use of short-lived radionuclides for research projects related to cancer, the heart and brain, diabetes, and infectious diseases. Imaging using PET radionuclides is becoming a remarkably useful translational tool for UW researchers, combining laboratory, small animal, and human protocols. The proposed instrument will provide PET radionuclides with short half-lives. The Radiochemistry Group uses these radionuclides to make radiochemicals for animal research studies and radiopharmaceuticals for human studies for a wide range of well-funded NIH investigators and others who are planning projects. In order to meet our need for short-lived isotopes (18F, 11C, 13N, 15O, 94mTc, 86Y and 124I), the cyclotron will be capable of irradiating two targets at the same time and have sufficient local shielding for siting it in existing space. The CTI RDS-111 cyclotron is the instrument that best meets our research needs. Although it has the lowest energy of the cyclotrons we considered, it has high current output and relatively low shielding requirements and it will meet our current and foreseeable future needs. The space for mounting targets is modular and designed for easy mounting of custom-built targets to make radionuclides for biomedical research projects that we may not even envision at this time. This cyclotron will be a productive research tool at UW for at least 20 years, well beyond the lifetime of most high-end instrumentation.

描述（由申请人提供）：该提案是一个新的回旋加速器，以支持华盛顿大学的成像研究。 对于医学成像来说，这是一个激动人心的时刻，新的成像工具正在开发并用于回答人类生物学前沿的重要问题。 UW分子成像中心是利用先进的方法对体内生化反应进行非侵入性成像的合作和创新研究的焦点。 我们的大多数研究将受益于回旋加速器利用定量正电子发射断层扫描（PET）的高空间和时间分辨率的能力。 华盛顿大学的PET项目已有17年的历史，是癌症和心脏成像研究的领导者。 到目前为止，我们已经在放射肿瘤科的回旋加速器上购买了时间。 我们现在需要一个专门的仪器来支持我们不断扩大的研究项目。 PET成像被我们医学院近一半的部门使用，包括基础科学和临床项目。 本申请描述了短寿命放射性核素在与癌症、心脏和大脑、糖尿病和传染病相关的研究项目中的应用。 使用PET放射性核素成像正在成为UW研究人员非常有用的翻译工具，结合实验室，小动物和人类协议。 拟议的仪器将提供半衰期短的PET放射性核素。 放射化学小组使用这些放射性核素为动物研究研究制造放射性化学品，并为大量资金充足的NIH研究人员和其他正在规划项目的人制造用于人类研究的放射性药物。 为了满足我们对短寿命同位素（18F，11 C，13 N，15 O，94 mTc，86 Y和124 I）的需求，回旋加速器将能够同时照射两个目标，并具有足够的局部屏蔽，以便将其放置在现有空间中。 CTI RDS-111回旋加速器是最能满足我们研究需求的仪器。 虽然它具有我们考虑的回旋加速器的最低能量，但它具有高电流输出和相对较低的屏蔽要求，并且它将满足我们当前和可预见的未来的需求。 安装靶的空间是模块化的，设计用于方便安装定制的靶，以制造放射性核素用于生物医学研究项目，我们甚至可能无法想象在这个时候。 这种回旋加速器将成为华盛顿大学至少20年的生产性研究工具，远远超过大多数高端仪器的使用寿命。