CORE--RADIOCHEMISTRY

核心--放射化学

• 批准号: 6300264
• 负责人: KENNETH A. KROHN
• 金额: $ 28.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6300264
• 关键词: biomedical facility; radiochemistry

The radiochemistry core provides the radiopharmaceuticals as requested by the projects to fulfill the goals of the research described in this application. The specific aims are to produce C-11 and F-18, and to use these radionuclides to prepared the radioactive precursors: [C-11]NH4CN, [C-11]CH3I, and [F-18]fluoride, and to make the radiopharmaceuticals 2-[C- 11]thymidine; -[C-11]glucose; [F-18]-2-fluorodeoxyglucose; [F- 18]fluoromisonidazole; and 16-alpha-[F-18]fluoroestradiol. Robot-assisted and remotely operated syntheses are used to make procedures more convenient and to make radiation exposure to the chemists as low as reasonably used to make procedures more convenient and to keep radiation exposure to the chemists as low as reasonably achievable. The radiochemists are responsible for assuring the radiochemical purity and pharmaceutical quality of all products for in vivo studies and for compliance with all regulations regarding radiation and pharmaceutical safety.

放射化学核心提供放射性药物， 实现本报告所述研究目标的项目 应用程序.具体目标是生产C-11和F-18， 这些放射性核素制备放射性前体：[C-11] NH 4 CN， [C-11] CH 3 I和[F-18]氟化物，并制备放射性药物2-[C-11] CH 3 I和[F-18]氟化物。 11]胸苷; -[C-11]葡萄糖; [F-18]-2-氟脱氧葡萄糖; [F- 18]氟咪唑;和16-α-[F-18]氟雌二醇。机器人辅助 和远程操作的合成被用来使程序更 方便，并使化学家的辐射暴露低至 合理使用，使手术更方便， 尽可能低地暴露于化学家。的 放射化学家负责确保放射化学纯度， 用于体内研究的所有产品的药物质量， 遵守所有有关辐射和药物的规定 安全为代价的