BIOCHEMISTRY AND IMMUNOLOGY OF ALCOHOLIC LIVER DISEASE

酒精性肝病的生物化学和免疫学

• 批准号: 6509160
• 负责人: THOMAS R JERRELLS
• 金额: $ 23.06万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509160
• 关键词: BIOCHEMISTRY; IMMUNOLOGY; ALCOHOLIC; LIVER; DISEASE

DESCRIPTION: Alcoholic liver disease is a serious world-wide problem. Although a large amount of research has been done to determine the mechanisms that are responsible for liver damage associated with alcohol abuse it is still not clear what the mechanisms are that result in hepatocyte damage. There is a need for well-trained basic scientists to do research on the cellular and molecular biological aspects of alcoholic liver disease. It is a very recent finding that alcohol abuse is associated with a more severe hepatitis caused by hepatitis C virus, which has further supported the suggestion that there is an association between the suppression of immune responses and an increased susceptibility to infectious agents such as the hepatitis viruses. Very little information is available regarding the mechanisms that lead to more severe infections with these viruses and there is a clear need for individuals trained in this aspect of alcohol's effects. There is a need for clinically trained researchers with an understanding of research. The creation of numerous MD/PhD programs has been proposed to fill the need for research-trained clinicians. It is one aspect of the proposed training grant to train MD/PhD students to assume positions where clinical research on the mechanisms of alcoholic liver disease can be performed. It is proposed that the training faculty located at the Omaha VA Medical Center in Omaha, in collaboration with investigators at the University of Nebraska Medical Center and Creighton University, train pre-doctoral (including MD/PhD students) and post-doctoral students in research in the fundamental mechanisms of alcoholic Ever disease. 'Me training faculty have academic appointments at the University of Nebraska Medical Center and are actively funded to do research and have extensive experience in training pre- and post-doctoral students. Given the expertise of the training faculty, the extensive resources available to the trainees and the multidisciplinary approach to research on alcoholic liver disease at the Omaha VA research unit it is likely that each trainee will be well qualified to continue a research career in alcohol research. The ultimate goal of this training program is to prepare both basic scientists and clinically trained scientists for an active and productive research career on the effects of alcohol on the liver.

产品说明： 酒精性肝病是一个严重的世界性问题。虽然有很大一 大量的研究已经完成，以确定机制， 与酒精滥用有关的肝损伤， 明确导致肝细胞损伤的机制。有一个 需要训练有素的基础科学家来研究细胞和 酒精性肝病的分子生物学方面。这是一个非常近的 发现酗酒与更严重的肝炎有关， 丙型肝炎病毒，这进一步支持了这一建议， 免疫反应的抑制和免疫系统的 对感染因子如肝炎病毒的易感性。很少 关于导致更严重的 感染这些病毒，显然需要个人 在酒精的影响方面受过训练。 需要经过临床培训的研究人员了解 research.许多MD/博士课程的创建已被提议填补 需要经过研究训练的临床医生。这是拟议的一个方面， 培训补助金，以培训MD/PhD学生担任临床 可以对酒精性肝病的机制进行研究。 建议将位于奥马哈VA医疗中心的培训学院 中心在奥马哈，与研究人员在大学的合作， 内布拉斯加医学中心和克雷顿大学，培养博士预科 （包括MD/PhD学生）和博士后研究生 酒精性肝病的基本机制我的培训教师 内布拉斯加大学医学中心的学术任命， 积极资助做研究，并有丰富的培训经验前， 和博士后学生。 鉴于培训教师的专业知识，现有的广泛资源 和多学科的方法来研究酒精 奥马哈退伍军人管理局研究单位的肝病，很可能每个受训者 将很有资格继续在酒精研究的研究生涯。的 该培训计划的最终目标是培养基础科学家， 经过临床培训的科学家，从事积极和富有成效的研究事业， 酒精对肝脏的影响