OCT-BASED GLUCOSE SENSOR

美国大约有 1400 万人患有糖尿病。 目前的葡萄糖传感技术涉及每天多次手指穿刺以获得一滴血用于进一步分析。 许多公司和科学团体为无创地量化葡萄糖浓度付出了巨大的努力。 光学相干断层扫描（OCT）是一项蓬勃发展的技术，正在应用于组织中的高分辨率无创成像。 它利用对从组织中相干散射的光子进行灵敏检测。 我们提出了一种新型葡萄糖 OCT 传感器，其基础是精确测量皮肤的光散射，随着葡萄糖浓度的增加而减少。 我们在动物正常极化下进行的初步研究（推注和葡萄糖钳实验）的结果表明：（1）随着血糖浓度的增加，用 OCT 系统测量的组织散射急剧且线性减少；（2）推注葡萄糖引起的生理反应不会引起 150 至 500 μm 深度的组织散射变化。 该项目的具体目标是：（1）研究正常偏振和正交偏振下基于OCT的葡萄糖传感； (2) 在动物和临床研究中评估基于 OCT 的技术。 该项目的成功实施可能会导致便携式无创敏感葡萄糖传感器的开发，这将大大改善糖尿病患者的生活质量。

Approximately 14 million in the USA suffer from diabetes mellitus. The present glucose sensing technique involves a finger puncture several times a day to obtain a droplet of blood for further analysis. There have been enormous efforts by many companies and scientific groups to quantify glucose concentration noninvasively. Optical coherence tomography (OCT), booming technology, is being applied for noninvasive imaging in tissues with high resolution. It utilizes sensitive detection of photons coherently scattered from tissue. We propose a novel glucose OCT sensor based on precise measurement of light scattering from skin that decreases with the increase of glucose concentration. The results of our preliminary studies performed in normal polarization in animals (bolus injections and glucose clamping experiments) demonstrated: (1) sharp and linear decrease of tissue scattering measured with the OCT system with the increase of blood glucose concentration and (2) the changes in tissue scattering at the depth of 150 to 500 mum are not induced by physiologic response due to bolus glucose injections. Specific aims of the project are: (1) to study OCT-based glucose sensing in normal and orthogonal polarization; and (2) to evaluate the OCT-based technique in animal and clinical studies. Successful implementation of the project may result in the development of a portable noninvasive sensitive glucose sensor that will considerably improve the quality of life for diabetic patients.