OCT-BASED GLUCOSE SENSOR

在美国大约有1400万人患有糖尿病。 本发明的葡萄糖感测技术涉及一天数次手指穿刺以获得一滴血液用于进一步分析。 许多公司和科学团体已经做出了巨大的努力来非侵入性地量化葡萄糖浓度。 光学相干层析成像（OCT）是一种新兴的无创高分辨率成像技术。 它利用从组织相干散射的光子的灵敏检测。 我们提出了一种新的葡萄糖OCT传感器的基础上精确测量的光散射从皮肤，随着葡萄糖浓度的增加而减少。 我们的初步研究结果在正常极化的动物（团注和葡萄糖钳夹实验）证明：（1）急剧和线性下降的组织散射与OCT系统测量的血糖浓度的增加和（2）组织散射的变化在150至500 μ m的深度不是由生理反应引起的团注葡萄糖注射。 该项目的具体目标是：（1）研究基于OCT的正常和正交偏振葡萄糖传感;（2）在动物和临床研究中评估基于OCT的技术。 该项目的成功实施可能会导致便携式非侵入性敏感葡萄糖传感器的开发，这将大大提高糖尿病患者的生活质量。

Approximately 14 million in the USA suffer from diabetes mellitus. The present glucose sensing technique involves a finger puncture several times a day to obtain a droplet of blood for further analysis. There have been enormous efforts by many companies and scientific groups to quantify glucose concentration noninvasively. Optical coherence tomography (OCT), booming technology, is being applied for noninvasive imaging in tissues with high resolution. It utilizes sensitive detection of photons coherently scattered from tissue. We propose a novel glucose OCT sensor based on precise measurement of light scattering from skin that decreases with the increase of glucose concentration. The results of our preliminary studies performed in normal polarization in animals (bolus injections and glucose clamping experiments) demonstrated: (1) sharp and linear decrease of tissue scattering measured with the OCT system with the increase of blood glucose concentration and (2) the changes in tissue scattering at the depth of 150 to 500 mum are not induced by physiologic response due to bolus glucose injections. Specific aims of the project are: (1) to study OCT-based glucose sensing in normal and orthogonal polarization; and (2) to evaluate the OCT-based technique in animal and clinical studies. Successful implementation of the project may result in the development of a portable noninvasive sensitive glucose sensor that will considerably improve the quality of life for diabetic patients.