Optoacoustic monitoring of cerebral blood oxygenation

脑血氧饱和度的光声监测

• 批准号: 6680586
• 负责人: RINAT O. ESENALIEV
• 金额: $ 32.28万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6680586
• 关键词: biological signal transduction; blood; brain; clinical research; human middle age (35-64); human subject; human tissue; oximetry; oxygen transport; oxyhemoglobin; postmortem; respiratory gas; respiratory oxygen; respiratory oxygenation; technology /technique development; young adult human (21-34)

DESCRIPTION (provided by applicant): Management of acute, life-threatening neurologic illnesses, such as severe traumatic brain injury, is facilitated by accurate and continuous monitoring of cerebral oxygenation. However, current monitoring systems are invasive, requiring either cannulation of the internal jugular venous bulb or insertion of a probe directly into the brain. Nearinfrared spectroscopy, a noninvasive method of monitoring cerebral blood oxygenation, is promising, but has yet to be satisfactorily calibrated to provide quantitative measurement in adults. At present there is no system for accurate, noninvasive, and continuous monitoring of cerebral blood oxygenation. We proposed and performed in vitro and in vivo testing of a novel optoacoustic technique that accurately and continuously measures blood oxygenation directly from the superior sagittal sinus, a structure that can easily be localized due to the high resolution of the optoacoustic technique. The optoacoustic technique is based on generation of ultrasonic (optoacoustic) waves by laser pulses and detection of these waves by a sensitive acoustic transducer. Optoacoustic monitoring of blood oxygenation utilizes well-established differences in the optical absorption coefficients of oxy- and deoxyhemoglobin in the nearinfrared spectral range. During our current NIH R21 project supported by an NINDS grant under the Program Announcement PA-98-050 (directed at the development of innovative technologies including photoacoustic brain monitoring), we designed, built, and tested a noninvasive optoacoustic system for accurate monitoring of cerebral blood oxygenation. Our in vitro and in vivo (in sheep) studies demonstrated that: (1) the parameters of the optoacoustic waves are linearly dependent on blood oxygenation; (2) the use of specially designed transducers and optoacoustic probes allows sensitive detection despite optical and acoustic attenuation by thick bone; and (3) this technique can measure blood oxygenation with high accuracy. In this grant application, we propose to further develop this technique under this program announcement. The specific aims of the project are: (1) to modify the optoacoustic system to provide multiwavelength measurements and perform evaluation of the system in cadavers; (2) to evaluate it in vivo in volunteers; and (3) to evaluate the system performance in patients with traumatic brain injury. By the end of the project the system will be developed sufficiently to permit multi-center clinical trials.

描述（由申请人提供）： 通过准确，持续监测大脑氧合的监测，可以促进急性，威胁生命的神经系统疾病（例如严重的脑损伤）。但是，当前的监测系统是侵入性的，需要插管颈内静脉灯泡或直接插入大脑中的插管。近红外光谱是一种监测脑血氧的无创方法，有希望，但尚未令人满意地校准以提供成人的定量测量。目前，还没有对脑血氧的准确，无创和连续监测的系统。我们提出并在体外和体内进行了一种新型的光声技术，该技术直接从上矢状窦直接测量血液氧合，该结构由于光声技术的高分辨率而很容易定位。光声技术基于激光脉冲的产生超声波（光声），并通过敏感的声音传感器检测这些波。血液氧合的光声监测利用了近志光谱范围内的氧和脱氧血红蛋白的光吸收系数的良好差异。在我们目前的NIH R21项目中，我们在计划公告PA-98-050下的NINDS赠款（旨在开发包括光声脑监测在内的创新技术开发），我们设计，构建和测试了一种无创的光声系统，以准确地监测大脑血液氧化。我们的体外和体内（在绵羊中）的研究表明：（1）光声波的参数是线性取决于血液氧合的； （2）尽管通过厚骨进行光学和声学衰减，但使用特殊设计的换能器和光声探针允许敏感检测； （3）该技术可以高精度测量血液氧合。在此赠款应用程序中，我们建议在此计划公告下进一步开发此技术。该项目的具体目的是：（1）修改光声系统以提供多波长的测量结果并对尸体中的系统进行评估； （2）在志愿者中在体内评估它； （3）评估创伤性脑损伤患者的系统性能。到项目结束时，该系统将得到充分开发，以允许多中心临床试验。