Neural correlates of the precedence effect

优先效应的神经相关性

• 批准号: 6446458
• 负责人: KENNETH E HANCOCK
• 金额: $ 3.33万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6446458
• 关键词: afferent nerve; auditory pathways; auditory stimulus; brain mapping; cats; inferior colliculus; neural information processing; postdoctoral investigator; psychophysiology; sound perception

DESCRIPTION (provided by applicant): Two sounds separated by a brief interval are perceived as a single auditory image located near the lead stimulus. This property has been termed the "precedence effect" and is thought to be important for suppressing echoes when listening in reverberant environments. A complete understanding of the neural mechanisms underlying the precedence effect may lead to improvements in the design of binaural hearing aids and prosthetic devices that must operate in such environments. We propose to study these mechanisms in the inferior colliculus (IC), which is an important point of convergence in the ascending auditory system. When presented with two clicks separated by a delay, most neurons in the central nucleus of the IC show suppressed responses to the second click. This study seeks to identify which of these suppressive responses actually underlie the precedence effect. Specifically, responses to precedence effect stimuli will be segregated based on the origins of the afferent fibers that converge to shape those responses. The techniques will combine extracellular physiology and microinjections of the anatomical tracer Neurobiotin. Models will be developed to assess the ability of each identified subpopulation to predict psychophysical performance under precedence effect conditions. The data obtained will help identify more precisely the strategies employed by the auditory system to localize sound in complex acoustic environments.

描述（由申请人提供）：两个声音被短暂的间隔分开 被感知为位于导联刺激附近的单个听觉图像。这 财产被称为“优先效应”，被认为是重要的 用于在混响环境中收听时抑制回声。 对优先顺序背后的神经机制的完整理解 这种效果可能会导致双耳助听器设计的改进， 必须在这样的环境中工作的假肢装置。我们建议研究 这些机制在下丘（IC），这是一个重要的一点， 在提升听觉系统中的汇聚当出现两次点击 通过延迟分离，IC中央核中的大多数神经元显示 抑制对第二次点击的反应。本研究旨在确定哪些 实际上是优先效应的基础。 具体而言，对优先效应刺激的反应将基于 汇聚在一起形成这些反应的传入纤维的起源。 该技术将联合收割机细胞外生理学和显微注射的 解剖示踪剂神经生物素。将开发模型来评估 的每个确定的亚群，以预测心理物理性能下 优先效果条件。获得的数据将有助于确定更多 正是听觉系统用来定位声音的策略， 复杂的声学环境。