CRYSTALLOGRAPHIC ANALYSIS OF PARASITE PURINE SALVAGE ENZYMES

寄生虫嘌呤拯救酶的晶体分析

• 批准号: 6437551
• 负责人: PAMELA J FOCIA
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6437551
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; parasitism; proteins; radiography; structural biology

One striking difference in metabolism between humans and many parasites is that the parasites lack the ability to carry out the de novo synthesis of purine nucleotides, and are forced to rely on purine salvage enzymes to recycle purine bases from the host. Thus, these enzymes have been proposed as targets for antiparasite drug design. We are working on the structural analysis of three key parasite purine salvage enzymes.

人类和许多动物在新陈代谢方面有一个显著的不同