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BLNK PROTEINS IN B CELL RECEPTOR FUNCTION

B 细胞受体功能中的 BLNK 蛋白

基本信息

批准号：
6497096
负责人：
ANDREW C CHAN
金额：
$ 20.15万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-02-01 至 2003-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6497096
关键词：
B cell receptor B lymphocyte binding proteins biological signal transduction cell differentiation laboratory mouse phospholipase C phosphorylation protein structure function

项目摘要

DESCRIPTION: (Adapted from the Investigator's Abstract): Stimulation of t he B-cell antigen receptor (BCR) triggers the activation of at least 3 families of protein tyrosine kinases (PTKs). The sequential activation of these PTKs orchestrates a cascade of downstream signaling events, including activation of phospholipase C (PLC), and phosphorylation of the Shc adaptor protein and the Vav protooncogene. These proteins, in turn, drive the increases in cytoplasmic free Ca2+, Ras activation, and the activation of MAP kinases that couple BCR engagement to cell-cycle entry and alterations in gene expression. The investigator has identified two novel adapter proteins, designated BLNK- 1 and BLNK-2, that bind to PLC-gamma, Grb2, and Vav. These proteins exhibit sequence and functional homologies to the slp-76 adapter protein that appears to play a central role in signal transduction through the T-cell antigen receptor (TCR). The specific aims are: (1) to characterize BLNK-1 and BLNK-2 at the molecular and biochemical levels, (2) to define the biochemical and functional interactions of BLNK-1 and BLNK-2 with PLC-gamma, Grb2 and Vav, (3) to identify the phosphorylation sites within BLNK-1, and (4) to use genetic approaches to understand the role of BLNK proteins in B-cell development and normal B-cell function.

描述：（改编自研究者摘要）：刺激

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane.

DOI：
10.1084/jem.192.6.847
发表时间：
2000-09-18
期刊：
The Journal of experimental medicine
影响因子：
0
作者：
Ishiai M;Kurosaki M;Inabe K;Chan AC;Sugamura K;Kurosaki T
通讯作者：
Kurosaki T

Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase.

B 细胞连接蛋白的单倍体不足会增强表达有限剂量布鲁顿酪氨酸激酶的小鼠的 B 细胞信号传导缺陷。

DOI：
10.1093/intimm/dxg034
发表时间：
2003
期刊：
International immunology
影响因子：
4.4
作者：
Whyburn,LindseyR;Halcomb,KristinaE;Contreras,CristinaM;Pappu,Rajita;Witte,OwenN;Chan,AndrewC;Satterthwaite,AnneB
通讯作者：
Satterthwaite,AnneB

Functional complementation of BLNK by SLP-76 and LAT linker proteins.

SLP-76 和 LAT 连接蛋白对 BLNK 的功能互补。