STP & TIP ARE ESSENTIAL FOR HERPESVIRUS SAIMIRI ONCOGENICITY

C亚群疱疹病毒488株变异株的研究 在STP-C488或TIP中有缺失的情况下， 在细胞培养中检测了hvs突变体的转化潜能。 在普通绒猴中，亲本株与C亚群株488 永生化普通绒猴T淋巴细胞体外培养 白介素2不依赖生长，但两个缺失突变体都不是 产生了这样的生长转化野生型VS产生了致命的 淋巴瘤在实验感染后19至20天内常见 绒猴，VS ASTP-C488和VS ATIP为非致癌病毒 反复从绒猴的外周血液中分离出来 感染变异病毒超过5个月的这些结果 证明复制或复制不需要STP-C488和TIP 持久性，但每一种都是细胞培养中转化所必需的 对于常见的绒猴出版物Duboise中的淋巴瘤诱导， SM，郭，J，查查克，S，Desrosiers，RC和Jung，Ju STP和TIP是 疱疹病毒Saimiri致癌所必需的J Virol，1998； 72：1308-1313

Mutant forms of herpesvirus saimiri (HVS) subgroup C strain 488 with deletions in either STP-C488 or Tip were constructed The transforming potentials of the HVS mutants were tested in cell culture and in common marmosets Parental "VS subgroup C strain 488 immortalized common marmoset T lymphocytes in vitro to interleukin-2-independent growth, but neither of the deletion mutants produced such growth transformation Wild-type "VS produced fatal lymphoma within 19 to 20 days of experimental infection of common marmosets, while "VS ASTP-C488 and "VS ATip were nononcogenic Virus was repeatedly isolated from the peripheral blood of marmosets infected with mutant virus for more than 5 months These results demonstrate that STP-C488 and Tip are not required for replication or persistence, but each is essential for transformation in cell culture and for lymphoma induction in common marmosets PUBLICATIONS Duboise, SM, Guo, J, Czajak, S, Desrosiers, RC and Jung, JU STP and Tip are Essential for Herpesvirus Saimiri Oncogenicity J Virol 1998; 72:1308-1313