EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS

狼疮女性骨质疏松症的流行病学

• 批准号: 6411521
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 17.42万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6411521
• 关键词: African American; age difference; bone density; caucasian American; clinical research; comorbidity; disease /disorder proneness /risk; epidemiology; female; hip; human subject; interview; longitudinal human study; medical complication; menopause; osteoporosis; questionnaires; racial /ethnic difference; spine; statistics /biometry; systemic lupus erythematosus; women's health

Systemic lupus was once considered a fatal disease in young women, but patient mortality and morbidi have significantly improved in the last decade. As women with lupus approach a normal life expectancy, they are at risk for low bone mineral density (BMD). The precise frequency of low BMD in Caucasian and African-American women with SLE is unknown, although preliminary evidence has documented an increased frequency of low BMD and fractures in Caucasian women with lupus. The reasons for low BMD in lupus patients are unclear. Little is known on BMD or fractures in African-American women with lupus despite the fact that this racial group is afflicted by lupus three to four times as often as Caucasian women. Although corticosteroids may play a role, there is evidence that they may not be as important as other disease factors or alteration of traditional osteoporosis risk factor consequent to diagnosis and treatment. The overall goals of this project are to conduct both a cross-sectional study and a longitudinal study to determine the effect of lupus on low BMD and the rate of bone loss in 256 women with lupus and 256 close friend healthy controls matched for age, gender, race, and menopause status. BMD at the hip and lumbar spine and all risk factors will be measured at study entry and after two years of follow-up. Risk factors to be studied include: 1) traditional osteoporosis risk factors that may be affected by the consequences of the disease and/or its treatment (reproductive history, menstrual and menopause status, use of oral contraceptives and/or hormone replacement therapy, physical activity, and vitamin D levels); 2) disease specific risk factors (disease activity, disease severity, and renal disease); and 3) treatment related risk factors (corticosteroids and anticonvulsants). Data will be analyzed using t- tests, classification and regression trees (CART), and correlation and multiple regression analyses. This study will contribute to work done by other investigators by; examining the relationship between BMD and potentially reversible or preventable risk factors for low BMD. This information will direct the development of intervention strategies to prevent low BMD and subsequent fracture in these high risk patients.

系统性红斑狼疮曾被认为是年轻女性的致命疾病， 但在过去的一年中，患者死亡率和发病率都有了显著的改善。 十年。随着狼疮患者接近正常预期寿命，她们 有低骨密度(BMD)的风险。精准的 高加索和非裔美国女性低骨密度的发生率 系统性红斑狼疮尚不清楚，尽管初步证据表明 高加索女性低骨密度和骨折的发生率增加 患有狼疮。狼疮患者骨密度低的原因尚不清楚。 对患有骨质疏松症的非裔美国女性的骨密度或骨折知之甚少 狼疮，尽管这个种族受到三号狼疮的困扰 是高加索女性的四倍。虽然皮质类固醇 可能会发挥作用，但有证据表明，它们可能没有 其他疾病因素或改变传统骨质疏松症危险因素 作为诊断和治疗的结果。这个项目的总体目标是 该项目将进行横断面研究和纵向研究 狼疮对低骨密度的影响及骨质疏松症发生率的研究 256例女性狼疮患者和256例健康密友的骨丢失 年龄、性别、种族和更年期状况相匹配的对照。骨密度 在臀部和腰椎，所有危险因素将在 研究进入并经过两年的随访。有待研究的风险因素 包括：1)传统的骨质疏松症危险因素可能受 疾病和/或其治疗的后果(生殖 病史、月经和更年期状况、口服避孕药的使用情况 和/或激素替代疗法、体力活动和维生素D 水平)；2)疾病特有的风险因素(疾病活动、疾病 严重程度和肾脏疾病)；以及3)治疗相关危险因素 (皮质类固醇和抗惊厥药)。数据将使用t- 测试、分类和回归树(CART)以及相关性和 多元回归分析。这项研究将对所做的工作做出贡献 由其他调查人员通过；检查BMD和 低骨密度的潜在可逆或可预防的危险因素。这 信息将指导干预战略的发展，以 预防这些高危患者的低骨密度和继发骨折。